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@ARTICLE{Loeschcke:888810,
      author       = {Loeschcke, Anita and Thies, Stephan},
      title        = {{E}ngineering of natural product biosynthesis in
                      {P}seudomonas putida},
      journal      = {Current opinion in biotechnology},
      volume       = {65},
      issn         = {0958-1669},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2020-05224},
      pages        = {213 - 224},
      year         = {2020},
      abstract     = {Organisms from all kingdoms of life represent a rich source
                      for valuable natural products with various applications.
                      Microbial systems are useful to implement the expression of
                      respective biosynthetic genes and establish the production
                      and effective access to natural products, or to elucidate
                      the biochemistry of the underlying pathways. Pseudomonas
                      putida, a Gram-negative soil bacterium, appears to be
                      particularly suitable for natural product biosynthesis
                      because of an advantageous intrinsic metabolism and a
                      remarkable tolerance toward various xenobiotics. This
                      article presents the current state of engineering P. putida
                      for the biosynthesis of rhamnolipids, terpenoids,
                      polyketides, non-ribosomal peptides, and products from amino
                      acid metabolism. Technological advances facilitating
                      chromosomal integration and expression of biosynthetic
                      genes, and smart metabolic engineering are key to success.},
      cin          = {IMET},
      ddc          = {610},
      cid          = {I:(DE-Juel1)IMET-20090612},
      pnm          = {583 - Innovative Synergisms (POF3-583)},
      pid          = {G:(DE-HGF)POF3-583},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {32498036},
      UT           = {WOS:000589902000027},
      doi          = {10.1016/j.copbio.2020.03.007},
      url          = {https://juser.fz-juelich.de/record/888810},
}