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@ARTICLE{Holtbernd:888852,
      author       = {Holtbernd, Florian and Romanzetti, Sandro and Oertel,
                      Wolfgang Hermann and Knake, Susanne and Sittig, Elisabeth
                      and Heidbreder, Anna and Maier, Andrea and Krahe, Janna and
                      Wojtala, Jennifer and Dogan, Imis and Schulz, Jörg Bernhard
                      and Schiefer, Johannes and Janzen, Annette and Reetz,
                      Kathrin},
      title        = {{C}onvergent patterns of structural brain changes in rapid
                      eye movement sleep behavior disorder and {P}arkinson’s
                      disease on behalf of the {G}erman rapid eye movement sleep
                      behavior disorder study group},
      journal      = {Sleep},
      volume       = {44},
      number       = {3},
      issn         = {1550-9109},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2020-05266},
      pages        = {zsaa199},
      year         = {2021},
      abstract     = {Study ObjectivesRapid eye movement sleep behavior disorder
                      (RBD) is considered a prodromal state of Parkinson’s
                      disease (PD). We aimed to characterize patterns of
                      structural brain changes in RBD and PD patients using
                      multimodal MRI.MethodsA total of 30 patients with isolated
                      RBD, 29 patients with PD, and 56 age-matched healthy
                      controls (HC) underwent MRI at 3T, including tensor-based
                      morphometry, diffusion tensor imaging, and assessment of
                      cortical thickness.ResultsRBD individuals showed increased
                      volume of the right caudate nucleus compared with HC, and
                      higher cerebellar volume compared with both PD subjects and
                      HC. Similar to PD subjects, RBD patients displayed increased
                      fractional anisotropy (FA) in the corticospinal tracts,
                      several tracts mainly related to non-motor function, and
                      reduced FA of the corpus callosum compared with HC. Further,
                      RBD subjects showed higher FA in the cerebellar peduncles
                      and brainstem compared with both, PD patients and HC. PD
                      individuals exhibited lower than normal volume in the basal
                      ganglia, midbrain, pedunculopontine nuclei, and cerebellum.
                      In contrast, volume in PD subjects was increased in the
                      thalamus compared with both HC and RBD
                      subjects.ConclusionsWe found convergent patterns of
                      structural brain alterations in RBD and PD patients compared
                      with HC. The changes observed suggest a co-occurrence of
                      neurodegeneration and compensatory mechanisms that fail with
                      emerging PD pathology. Our findings strengthen the
                      hypothesis of RBD and PD constituting a continuous disease
                      spectrum.},
      cin          = {INM-4 / JARA-BRAIN / INM-11},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / $I:(DE-82)080010_20140620$ /
                      I:(DE-Juel1)INM-11-20170113},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {32974664},
      UT           = {WOS:000649380100016},
      doi          = {10.1093/sleep/zsaa199},
      url          = {https://juser.fz-juelich.de/record/888852},
}