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@ARTICLE{Tang:888853,
      author       = {Tang, Chris C. and Holtbernd, Florian and Ma, Yilong and
                      Spetsieris, Phoebe and Oh, Alice and Fink, Gereon R. and
                      Timmermann, Lars and Eggers, Carsten and Eidelberg, David},
      title        = {{H}emispheric {N}etwork {E}xpression in {P}arkinson’s
                      {D}isease: {R}elationship to {D}opaminergic {A}symmetries},
      journal      = {Journal of Parkinson's Disease},
      volume       = {10},
      number       = {4},
      issn         = {1877-718X},
      address      = {Amsterdam},
      publisher    = {IOS Press},
      reportid     = {FZJ-2020-05267},
      pages        = {1737 - 1749},
      year         = {2020},
      abstract     = {Background:Parkinson’s disease (PD) is characterized by
                      brain metabolic networks, specifically associated with motor
                      and cognitive manifestations. Few studies have investigated
                      network changes in cerebral hemispheres ipsilateral and
                      contralateral to the clinically more affected body
                      side.Objective:We examined hemispheric network abnormalities
                      and their relationship to striatal dopaminergic deficits in
                      PD patients at different stages.Methods:45 PD patients
                      underwent dual-tracer positron emission tomography (PET)
                      with 18F-fluorodeoxyglucose (FDG) and 18F-fluorodopa (FDOPA)
                      in a high-resolution PET scanner. In all patients, we
                      computed expression levels for the PD-related
                      motor/cognition metabolic patterns (PDRP/PDCP) as well as
                      putamen/caudate FDOPA uptake values in both hemispheres.
                      Resulting hemispheric measures in the PD group were compared
                      with corresponding healthy control values and assessed
                      across disease stages.Results:Hemispheric PDRP and PDCP
                      expression was significantly elevated contralateral and
                      ipsilateral to the more affected body side in patients with
                      unilateral symptoms $(H\&Y$ 1: p < 0.01) and in patients
                      with bilateral limb involvement $(H\&Y$ 2-3: p < 0.001;
                      $H\&Y$ 4: p < 0.003). Elevations in pattern expression
                      were symmetrical at all disease stages. By contrast, FDOPA
                      uptake in the caudate and putamen was reduced bilaterally
                      (p < 0.002), with lower values on both sides at more
                      advanced disease stages. Hemispheric uptake was asymmetrical
                      in both striatal regions, with lower contralateral values at
                      all disease stages. The magnitude of hemispheric uptake
                      asymmetry was smaller with more advanced disease, reflecting
                      greater change ipsilaterally.Conclusion:Symmetrical network
                      expression in PD represents bilateral functional effects
                      unrelated to nigrostriatal dopaminergic asymmetries.},
      cin          = {INM-4 / INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-3-20090406},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {32925097},
      UT           = {WOS:000587725300043},
      doi          = {10.3233/JPD-202117},
      url          = {https://juser.fz-juelich.de/record/888853},
}