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000888945 1001_ $$0P:(DE-HGF)0$$aSteffen, Julia K.$$b0$$eCorresponding author
000888945 245__ $$aThalamic Deep Brain Stimulation in Essential Tremor Plus Is as Effective as in Essential Tremor
000888945 260__ $$aBasel$$bMDPI AG$$c2020
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000888945 520__ $$aThe new essential tremor (ET) classification defined ET-plus (ET-p) as an ET subgroup with additional neurological signs besides action tremor. While deep brain stimulation (DBS) is effective in ET, there are no studies specifically addressing DBS effects in ET-p. 44 patients with medication-refractory ET and thalamic/subthalamic DBS implanted at our center were postoperatively classified into ET and ET-p according to preoperative documentation. Tremor suppression with DBS (stimulation ON vs. preoperative baseline and vs. stimulation OFF), measured via the Fahn–Tolosa–Marin tremor rating scale (TRS), stimulation parameters, and the location of active contacts were compared between patients classified as ET and ET-p. TRS scores at baseline were higher in ET-p. ET-p patients showed comparable tremor reduction as patients with ET, albeit higher stimulation parameters were needed in ET-p. Active electrode contacts were located more dorsally in ET-p of uncertain reason. Our data show that DBS is similarly effective in ET-p compared to ET. TRS scores were higher in ET-p preoperatively, and higher stimulation parameters were needed for tremor reduction compared to ET. The latter may be related to a more dorsal location of active electrode contacts in the ET-p group of this cohort. Prospective studies are warranted to investigate DBS in ET-p further
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000888945 7001_ $$0P:(DE-HGF)0$$aJergas, Hannah$$b1
000888945 7001_ $$0P:(DE-HGF)0$$aPetry-Schmelzer, Jan N.$$b2
000888945 7001_ $$00000-0001-7023-146X$$aDembek, Till A.$$b3
000888945 7001_ $$00000-0001-9149-3143$$aThies, Tabea$$b4
000888945 7001_ $$0P:(DE-HGF)0$$aJost, Stefanie T.$$b5
000888945 7001_ $$0P:(DE-HGF)0$$aDafsari, Haidar S.$$b6
000888945 7001_ $$0P:(DE-HGF)0$$aKessler, Josef$$b7
000888945 7001_ $$0P:(DE-HGF)0$$aWirths, Jochen$$b8
000888945 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon R.$$b9$$ufzj
000888945 7001_ $$0P:(DE-HGF)0$$aVisser-Vandewalle, Veerle$$b10
000888945 7001_ $$0P:(DE-Juel1)131613$$aBarbe, Michael T.$$b11
000888945 773__ $$0PERI:(DE-600)2651993-8$$a10.3390/brainsci10120970$$gVol. 10, no. 12, p. 970 -$$n12$$p970 -$$tBrain Sciences$$v10$$x2076-3425$$y2020
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