TY  - JOUR
AU  - Steffen, Julia K.
AU  - Jergas, Hannah
AU  - Petry-Schmelzer, Jan N.
AU  - Dembek, Till A.
AU  - Thies, Tabea
AU  - Jost, Stefanie T.
AU  - Dafsari, Haidar S.
AU  - Kessler, Josef
AU  - Wirths, Jochen
AU  - Fink, Gereon R.
AU  - Visser-Vandewalle, Veerle
AU  - Barbe, Michael T.
TI  - Thalamic Deep Brain Stimulation in Essential Tremor Plus Is as Effective as in Essential Tremor
JO  - Brain Sciences
VL  - 10
IS  - 12
SN  - 2076-3425
CY  - Basel
PB  - MDPI AG
M1  - FZJ-2020-05344
SP  - 970 -
PY  - 2020
AB  - The new essential tremor (ET) classification defined ET-plus (ET-p) as an ET subgroup with additional neurological signs besides action tremor. While deep brain stimulation (DBS) is effective in ET, there are no studies specifically addressing DBS effects in ET-p. 44 patients with medication-refractory ET and thalamic/subthalamic DBS implanted at our center were postoperatively classified into ET and ET-p according to preoperative documentation. Tremor suppression with DBS (stimulation ON vs. preoperative baseline and vs. stimulation OFF), measured via the Fahn–Tolosa–Marin tremor rating scale (TRS), stimulation parameters, and the location of active contacts were compared between patients classified as ET and ET-p. TRS scores at baseline were higher in ET-p. ET-p patients showed comparable tremor reduction as patients with ET, albeit higher stimulation parameters were needed in ET-p. Active electrode contacts were located more dorsally in ET-p of uncertain reason. Our data show that DBS is similarly effective in ET-p compared to ET. TRS scores were higher in ET-p preoperatively, and higher stimulation parameters were needed for tremor reduction compared to ET. The latter may be related to a more dorsal location of active electrode contacts in the ET-p group of this cohort. Prospective studies are warranted to investigate DBS in ET-p further
LB  - PUB:(DE-HGF)16
C6  - 33322350
UR  - <Go to ISI:>//WOS:000601873400001
DO  - DOI:10.3390/brainsci10120970
UR  - https://juser.fz-juelich.de/record/888945
ER  -