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@ARTICLE{Steffen:888945,
      author       = {Steffen, Julia K. and Jergas, Hannah and Petry-Schmelzer,
                      Jan N. and Dembek, Till A. and Thies, Tabea and Jost,
                      Stefanie T. and Dafsari, Haidar S. and Kessler, Josef and
                      Wirths, Jochen and Fink, Gereon R. and Visser-Vandewalle,
                      Veerle and Barbe, Michael T.},
      title        = {{T}halamic {D}eep {B}rain {S}timulation in {E}ssential
                      {T}remor {P}lus {I}s as {E}ffective as in {E}ssential
                      {T}remor},
      journal      = {Brain Sciences},
      volume       = {10},
      number       = {12},
      issn         = {2076-3425},
      address      = {Basel},
      publisher    = {MDPI AG},
      reportid     = {FZJ-2020-05344},
      pages        = {970 -},
      year         = {2020},
      abstract     = {The new essential tremor (ET) classification defined
                      ET-plus (ET-p) as an ET subgroup with additional
                      neurological signs besides action tremor. While deep brain
                      stimulation (DBS) is effective in ET, there are no studies
                      specifically addressing DBS effects in ET-p. 44 patients
                      with medication-refractory ET and thalamic/subthalamic DBS
                      implanted at our center were postoperatively classified into
                      ET and ET-p according to preoperative documentation. Tremor
                      suppression with DBS (stimulation ON vs. preoperative
                      baseline and vs. stimulation OFF), measured via the
                      Fahn–Tolosa–Marin tremor rating scale (TRS), stimulation
                      parameters, and the location of active contacts were
                      compared between patients classified as ET and ET-p. TRS
                      scores at baseline were higher in ET-p. ET-p patients showed
                      comparable tremor reduction as patients with ET, albeit
                      higher stimulation parameters were needed in ET-p. Active
                      electrode contacts were located more dorsally in ET-p of
                      uncertain reason. Our data show that DBS is similarly
                      effective in ET-p compared to ET. TRS scores were higher in
                      ET-p preoperatively, and higher stimulation parameters were
                      needed for tremor reduction compared to ET. The latter may
                      be related to a more dorsal location of active electrode
                      contacts in the ET-p group of this cohort. Prospective
                      studies are warranted to investigate DBS in ET-p further},
      cin          = {INM-3},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33322350},
      UT           = {WOS:000601873400001},
      doi          = {10.3390/brainsci10120970},
      url          = {https://juser.fz-juelich.de/record/888945},
}