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@ARTICLE{Refisch:888984,
      author       = {Refisch, Alexander and Chung, Ha-Yeun and Komatsuzaki,
                      Shoko and Schumann, Andy and Mühleisen, Thomas W. and
                      Nöthen, Markus M. and Hübner, Christian A. and Bär,
                      Karl-Jürgen},
      title        = {{A} common variation in {HCN}1 is associated with heart
                      rate variability in schizophrenia},
      journal      = {Schizophrenia research},
      volume       = {229},
      issn         = {0920-9964},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2020-05371},
      pages        = {73-79},
      year         = {2021},
      abstract     = {BackgroundThere is growing evidence for a shared genetic
                      basis between schizophrenia risk and cardiovascular disease.
                      Reduced efferent vagal activity, indexed by reduced heart
                      rate variability (HRV), has been consistently described in
                      patients with schizophrenia and may potentially contribute
                      to the increased cardiovascular risk in these patients. In
                      this study, we tested the hypothesis whether the established
                      schizophrenia risk variant HCN1 rs16902086 (A > G) is
                      associated with reduced HRV.MethodsWe analyzed the risk
                      status of HCN1 rs16902086 (AG/GG vs. AA genotype) in 83
                      unmedicated patients with schizophrenia and 96 healthy
                      controls and investigated genotype-related impacts on
                      various HRV parameters.ResultsWe observed significantly
                      increased resting heart rates and a marked decrease of vagal
                      modulation in our patient cohort. Strikingly, HCN1
                      rs16902086 (A > G) was associated with reduced HRV
                      parameters in patients only. A trend towards more pronounced
                      HRV deviations was observed in homozygous (GG) compared to
                      heterozygous patients (AG).ConclusionWe present first
                      evidence for a genetic risk factor that is associated with
                      decreased vagal modulation in unmedicated patients with
                      schizophrenia. Moreover, our findings suggest that HCN1
                      might be involved in reduced vagal modulation and possibly
                      in increased cardiac mortality in schizophrenia patients.
                      Thus, our data indicate that reduced vagal modulation might
                      be an endophenotype of schizophrenia.},
      cin          = {INM-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33221148},
      UT           = {WOS:000664029200013},
      doi          = {10.1016/j.schres.2020.11.017},
      url          = {https://juser.fz-juelich.de/record/888984},
}