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@ARTICLE{Gehlen:889014,
      author       = {Gehlen, Jana and Esser, Stefan and Schaffrath, Kim and
                      Johnen, Sandra and Walter, Peter and Müller, Frank},
      title        = {{B}lockade of {R}etinal {O}scillations by {B}enzodiazepines
                      {I}mproves {E}fficiency of {E}lectrical {S}timulation in the
                      {M}ouse {M}odel of {RP}, rd10},
      journal      = {Investigative ophthalmology $\&$ visual science},
      volume       = {61},
      number       = {13},
      issn         = {1552-5783},
      address      = {Rockville, Md.},
      publisher    = {ARVO},
      reportid     = {FZJ-2020-05388},
      pages        = {37 -},
      year         = {2020},
      abstract     = {Purpose: In RP, photoreceptors degenerate. Retinal
                      prostheses are considered a suitable strategy to restore
                      vision. In animal models of RP, a pathologic rhythmic
                      activity seems to compromise the efficiency of retinal
                      ganglion cell stimulation by an electrical prosthesis. We,
                      therefore, strove to eliminate this pathologic
                      activity.Methods: Electrophysiologic recordings of local
                      field potentials and spike activity of retinal ganglion
                      cells were obtained in vitro from retinae of wild-type and
                      rd10 mice using multielectrode arrays. Retinae were
                      stimulated electrically.Results: The efficiency of
                      electrical stimulation was lower in rd10 retina than in
                      wild-type retina and this was highly correlated with the
                      presence of oscillations in retinal activity. Glycine and
                      GABA, as well as the benzodiazepines diazepam, lorazepam,
                      and flunitrazepam, abolished retinal oscillations and, most
                      important, increased the efficiency of electrical
                      stimulation to values similar to those in wild-type
                      retina.Conclusions: Treatment of patients with these
                      benzodiazepines may offer a way to improve the performance
                      of retinal implants in cases with poor implant proficiency.
                      This study may open the way to a therapy that supports
                      electrical stimulation by prostheses with pharmacologic
                      treatment.},
      cin          = {IBI-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)IBI-1-20200312},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33252632},
      UT           = {WOS:000595313500031},
      doi          = {10.1167/iovs.61.13.37},
      url          = {https://juser.fz-juelich.de/record/889014},
}