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@ARTICLE{Berkamp:889053,
      author       = {Berkamp, Sabrina and Mostafavi, Siavash and Sachse,
                      Carsten},
      title        = {{S}tructure and function of p62/{SQSTM}1 in the emerging
                      framework of phase separation},
      journal      = {The FEBS journal},
      volume       = {28},
      number       = {24},
      issn         = {1742-4658},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {FZJ-2020-05421},
      pages        = {6927-6941},
      year         = {2020},
      abstract     = {p62/SQSTM1 is a multiprotein interaction hub forming
                      cellular punctate structures known as p62 bodies. p62 is
                      centrally involved in the degradation of ubiquitinated cargo
                      through autophagy, as well as in a wide range of signaling
                      activities as part of the cellular response to nutrient
                      sensing, oxidative stress, infection, immunity, and
                      inflammation. Structural work has shown that p62 forms
                      flexible filamentous assemblies composed of an N-terminal
                      PB1-domain scaffold and a C-terminal binding platform,
                      including folded recognition domains and structurally
                      disordered binding motifs. In the cell, these filaments are
                      part of cellular p62 bodies that display properties of
                      liquid–liquid-phase separation. Here, we review the
                      accumulated structural and functional work of p62 and
                      integrate them with the emerging framework of filamentous
                      biomolecular condensates.},
      cin          = {ER-C-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)ER-C-3-20170113},
      pnm          = {551 - Functional Macromolecules and Complexes (POF3-551)},
      pid          = {G:(DE-HGF)POF3-551},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33332721},
      UT           = {WOS:000603404600001},
      doi          = {10.1111/febs.15672},
      url          = {https://juser.fz-juelich.de/record/889053},
}