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@ARTICLE{Becker:889069,
      author       = {Becker, Johanna and Hosseinpour Tehrani, Hamed and Ernst,
                      Philipp and Blank, Lars Mathias and Wierckx, Nick},
      title        = {{A}n {O}ptimized {U}stilago maydis for {I}taconic {A}cid
                      {P}roduction at {M}aximal {T}heoretical {Y}ield},
      journal      = {Journal of Fungi},
      volume       = {7},
      number       = {1},
      issn         = {2309-608X},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {FZJ-2021-00007},
      pages        = {20 -},
      year         = {2021},
      abstract     = {Ustilago maydis, a member of the Ustilaginaceae family, is
                      a promising host for the production of several metabolites
                      including itaconic acid. This dicarboxylate has great
                      potential as a bio-based building block in the polymer
                      industry, and is of special interest for pharmaceutical
                      applications. Several itaconate overproducing Ustilago
                      strains have been generated by metabolic and morphology
                      engineering. This yielded stabilized unicellular morphology
                      through fuz7 deletion, reduction of by-product formation
                      through deletion of genes responsible for itaconate
                      oxidation and (glyco)lipid production, and the
                      overexpression of the regulator of the itaconate cluster
                      ria1 and the mitochondrial tricarboxylate transporter
                      encoded by mttA from Aspergillusterreus. In this study,
                      itaconate production was further optimized by consolidating
                      these different optimizations into one strain. The combined
                      modifications resulted in itaconic acid production at
                      theoretical maximal yield, which was achieved under
                      biotechnologically relevant fed-batch fermentations with
                      continuous feed.},
      cin          = {IBG-1},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IBG-1-20101118},
      pnm          = {2172 - Utilization of renewable carbon and energy sources
                      and engineering of ecosystem functions (POF4-217)},
      pid          = {G:(DE-HGF)POF4-2172},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33396473},
      UT           = {WOS:000610334500001},
      doi          = {10.3390/jof7010020},
      url          = {https://juser.fz-juelich.de/record/889069},
}