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@ARTICLE{Machado:889102,
      author       = {Machado, Daniel and Maistrenko, Oleksandr M. and Andrejev,
                      Sergej and Kim, Yongkyu and Bork, Peer and Patil, Kaustubh
                      R. and Patil, Kiran R.},
      title        = {{P}olarization of microbial communities between competitive
                      and cooperative metabolism},
      journal      = {Nature ecology $\&$ evolution},
      volume       = {5},
      issn         = {2397-334X},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {FZJ-2021-00032},
      pages        = {195–203},
      year         = {2021},
      abstract     = {Resource competition and metabolic cross-feeding are among
                      the main drivers of microbial community assembly. Yet the
                      degree to which these two conflicting forces are reflected
                      in the composition of natural communities has not been
                      systematically investigated. Here, we use genome-scale
                      metabolic modelling to assess the potential for resource
                      competition and metabolic cooperation in large co-occurring
                      groups (up to 40 members) across thousands of habitats. Our
                      analysis reveals two distinct community types, which are
                      clustered at opposite ends of a spectrum in a trade-off
                      between competition and cooperation. At one end are highly
                      cooperative communities, characterized by smaller genomes
                      and multiple auxotrophies. At the other end are highly
                      competitive communities, which feature larger genomes and
                      overlapping nutritional requirements, and harbour more genes
                      related to antimicrobial activity. The latter are mainly
                      present in soils, whereas the former are found in both
                      free-living and host-associated habitats. Community-scale
                      flux simulations show that, whereas competitive communities
                      can better resist species invasion but not nutrient shift,
                      cooperative communities are susceptible to species invasion
                      but resilient to nutrient change. We also show, by analysing
                      an additional data set, that colonization by probiotic
                      species is positively associated with the presence of
                      cooperative species in the recipient microbiome. Together,
                      our results highlight the bifurcation between competitive
                      and cooperative metabolism in the assembly of natural
                      communities and its implications for community modulation.},
      cin          = {INM-7},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33398106},
      UT           = {WOS:000604843800006},
      doi          = {10.1038/s41559-020-01353-4},
      url          = {https://juser.fz-juelich.de/record/889102},
}