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000889131 1001_ $$0P:(DE-HGF)0$$aLa Joie, Renaud$$b0$$eCorresponding author
000889131 245__ $$aThe development of a valid, reliable, harmonized segmentation protocol for hippocampal subfields and medial temporal lobe cortices: A progress update
000889131 260__ $$aHoboken, NJ$$bWiley$$c2020
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000889131 520__ $$aBackgroundThe medial temporal lobe (MTL, i.e. hippocampus and adjacent cortices) is particularly vulnerable to age‐related diseases: Alzheimer’s disease, other age‐related proteinothies (TDP‐43, AGD, etc) and vascular injury. Yet, the subregional pattern of vulnerability is thought to differ across etiologies; characterizing these differences using high‐resolution MRI may provide more insight in disease processes and better biomarkers. However, substantial differences in subfield definition has hindered the ability to compare results across laboratories or draw robust conclusions (Figure 1). The Hippocampal Subfields Group (HSG) is an international group seeking to remedy this problem by developing a histologically‐valid, reliable, and freely available segmentation protocol for high‐resolution T2‐weighted 3T MRI (http://www.hippocampalsubfields.com)MethodOur workflow consists of five steps: 1) collecting histology samples labeled by multiple expert neuroanatomists to form a novel reference dataset to guide the development of the MRI segmentation protocol, 2) developing boundary definitions for each segment of the hippocampus, (head, body, and tail) and MTL cortices), 3) assessing HSG community agreement with boundary rules via online questionnaires and revising boundary rules based on questionnaire responses, and 4) testing reliability of the protocol definitions on multiple MRI datasets.ResultFor both the hippocampal body and head, we have developed a preliminary subfield segmentation protocol (i.e. completed steps 1‐2, see Figure 2 for a histology slice segmented by three anatomists). Step 3 was piloted for the outer boundaries of the body (i.e., the anterior/posterior, medial/lateral, and superior/inferior boundaries) using an online questionnaire describing each of the proposed rules. 29 labs participated and consensus agreement was reached for all rules, with only minor changes being made to improve comprehension and clarity. We are now creating and administering additional questionnaires for assessing agreement of the hippocampal body and head inner boundary rules (e.g., between the CA fields and dentate gyrus). Upon completion of the assessment/revision process for each set of rules, the final phase – reliability testing of the protocol – should begin mid 2020 for the body.ConclusionOnce completed, the harmonized protocol will significantly facilitate cross‐study comparisons thus advancing insight in the role of hippocampal subfields across the lifespan in aging and disease.
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000889131 7001_ $$0P:(DE-HGF)0$$aOlsen, Rosanna$$b1
000889131 7001_ $$0P:(DE-HGF)0$$aBerron, David$$b2
000889131 7001_ $$0P:(DE-Juel1)131631$$aAmunts, Katrin$$b3
000889131 7001_ $$0P:(DE-HGF)0$$aAugustinack, Jean$$b4
000889131 7001_ $$0P:(DE-HGF)0$$aBakker, Arnold$$b5
000889131 7001_ $$0P:(DE-HGF)0$$aBender, Andrew$$b6
000889131 7001_ $$0P:(DE-HGF)0$$aBoccardi, Marina$$b7
000889131 7001_ $$0P:(DE-HGF)0$$aBocchetta, Martina$$b8
000889131 7001_ $$0P:(DE-HGF)0$$aChakravarty, M. Mallar$$b9
000889131 7001_ $$0P:(DE-HGF)0$$aChetelat, Gael$$b10
000889131 7001_ $$0P:(DE-HGF)0$$ade Flores, Robin$$b11
000889131 7001_ $$0P:(DE-HGF)0$$aDeKraker, Jordan$$b12
000889131 7001_ $$0P:(DE-HGF)0$$aDing, Song-Lin$$b13
000889131 7001_ $$0P:(DE-HGF)0$$aInsausti, Ricardo$$b14
000889131 7001_ $$0P:(DE-Juel1)131650$$aKedo, Olga$$b15
000889131 7001_ $$aMueller, Susanne G$$b16
000889131 7001_ $$aOfen, Noa$$b17
000889131 7001_ $$aPalombo, Daniela$$b18
000889131 7001_ $$aRaz, Naftali$$b19
000889131 7001_ $$aStark, Craig E.$$b20
000889131 7001_ $$0P:(DE-HGF)0$$aWang, Lei$$b21
000889131 7001_ $$aYushkevich, Paul A.$$b22
000889131 7001_ $$aYu, Qijing$$b23
000889131 7001_ $$aCarr, Valerie A$$b24
000889131 7001_ $$aWisse, Laura$$b25
000889131 7001_ $$aDaugherty, Ana M.$$b26
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