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@ARTICLE{LaJoie:889131,
author = {La Joie, Renaud and Olsen, Rosanna and Berron, David and
Amunts, Katrin and Augustinack, Jean and Bakker, Arnold and
Bender, Andrew and Boccardi, Marina and Bocchetta, Martina
and Chakravarty, M. Mallar and Chetelat, Gael and de Flores,
Robin and DeKraker, Jordan and Ding, Song-Lin and Insausti,
Ricardo and Kedo, Olga and Mueller, Susanne G and Ofen, Noa
and Palombo, Daniela and Raz, Naftali and Stark, Craig E.
and Wang, Lei and Yushkevich, Paul A. and Yu, Qijing and
Carr, Valerie A and Wisse, Laura and Daugherty, Ana M.},
title = {{T}he development of a valid, reliable, harmonized
segmentation protocol for hippocampal subfields and medial
temporal lobe cortices: {A} progress update},
journal = {Alzheimer's and dementia},
volume = {16},
number = {S4},
issn = {1552-5279},
address = {Hoboken, NJ},
publisher = {Wiley},
reportid = {FZJ-2021-00056},
pages = {e046652},
year = {2020},
note = {Kein Post-print vorhanden.},
abstract = {BackgroundThe medial temporal lobe (MTL, i.e. hippocampus
and adjacent cortices) is particularly vulnerable to
age‐related diseases: Alzheimer’s disease, other
age‐related proteinothies (TDP‐43, AGD, etc) and
vascular injury. Yet, the subregional pattern of
vulnerability is thought to differ across etiologies;
characterizing these differences using high‐resolution MRI
may provide more insight in disease processes and better
biomarkers. However, substantial differences in subfield
definition has hindered the ability to compare results
across laboratories or draw robust conclusions (Figure 1).
The Hippocampal Subfields Group (HSG) is an international
group seeking to remedy this problem by developing a
histologically‐valid, reliable, and freely available
segmentation protocol for high‐resolution T2‐weighted 3T
MRI (http://www.hippocampalsubfields.com)MethodOur workflow
consists of five steps: 1) collecting histology samples
labeled by multiple expert neuroanatomists to form a novel
reference dataset to guide the development of the MRI
segmentation protocol, 2) developing boundary definitions
for each segment of the hippocampus, (head, body, and tail)
and MTL cortices), 3) assessing HSG community agreement with
boundary rules via online questionnaires and revising
boundary rules based on questionnaire responses, and 4)
testing reliability of the protocol definitions on multiple
MRI datasets.ResultFor both the hippocampal body and head,
we have developed a preliminary subfield segmentation
protocol (i.e. completed steps 1‐2, see Figure 2 for a
histology slice segmented by three anatomists). Step 3 was
piloted for the outer boundaries of the body (i.e., the
anterior/posterior, medial/lateral, and superior/inferior
boundaries) using an online questionnaire describing each of
the proposed rules. 29 labs participated and consensus
agreement was reached for all rules, with only minor changes
being made to improve comprehension and clarity. We are now
creating and administering additional questionnaires for
assessing agreement of the hippocampal body and head inner
boundary rules (e.g., between the CA fields and dentate
gyrus). Upon completion of the assessment/revision process
for each set of rules, the final phase – reliability
testing of the protocol – should begin mid 2020 for the
body.ConclusionOnce completed, the harmonized protocol will
significantly facilitate cross‐study comparisons thus
advancing insight in the role of hippocampal subfields
across the lifespan in aging and disease.},
cin = {INM-1},
ddc = {610},
cid = {I:(DE-Juel1)INM-1-20090406},
pnm = {571 - Connectivity and Activity (POF3-571)},
pid = {G:(DE-HGF)POF3-571},
typ = {PUB:(DE-HGF)16},
doi = {10.1002/alz.046652},
url = {https://juser.fz-juelich.de/record/889131},
}