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@ARTICLE{LaJoie:889131,
      author       = {La Joie, Renaud and Olsen, Rosanna and Berron, David and
                      Amunts, Katrin and Augustinack, Jean and Bakker, Arnold and
                      Bender, Andrew and Boccardi, Marina and Bocchetta, Martina
                      and Chakravarty, M. Mallar and Chetelat, Gael and de Flores,
                      Robin and DeKraker, Jordan and Ding, Song-Lin and Insausti,
                      Ricardo and Kedo, Olga and Mueller, Susanne G and Ofen, Noa
                      and Palombo, Daniela and Raz, Naftali and Stark, Craig E.
                      and Wang, Lei and Yushkevich, Paul A. and Yu, Qijing and
                      Carr, Valerie A and Wisse, Laura and Daugherty, Ana M.},
      title        = {{T}he development of a valid, reliable, harmonized
                      segmentation protocol for hippocampal subfields and medial
                      temporal lobe cortices: {A} progress update},
      journal      = {Alzheimer's and dementia},
      volume       = {16},
      number       = {S4},
      issn         = {1552-5279},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {FZJ-2021-00056},
      pages        = {e046652},
      year         = {2020},
      note         = {Kein Post-print vorhanden.},
      abstract     = {BackgroundThe medial temporal lobe (MTL, i.e. hippocampus
                      and adjacent cortices) is particularly vulnerable to
                      age‐related diseases: Alzheimer’s disease, other
                      age‐related proteinothies (TDP‐43, AGD, etc) and
                      vascular injury. Yet, the subregional pattern of
                      vulnerability is thought to differ across etiologies;
                      characterizing these differences using high‐resolution MRI
                      may provide more insight in disease processes and better
                      biomarkers. However, substantial differences in subfield
                      definition has hindered the ability to compare results
                      across laboratories or draw robust conclusions (Figure 1).
                      The Hippocampal Subfields Group (HSG) is an international
                      group seeking to remedy this problem by developing a
                      histologically‐valid, reliable, and freely available
                      segmentation protocol for high‐resolution T2‐weighted 3T
                      MRI (http://www.hippocampalsubfields.com)MethodOur workflow
                      consists of five steps: 1) collecting histology samples
                      labeled by multiple expert neuroanatomists to form a novel
                      reference dataset to guide the development of the MRI
                      segmentation protocol, 2) developing boundary definitions
                      for each segment of the hippocampus, (head, body, and tail)
                      and MTL cortices), 3) assessing HSG community agreement with
                      boundary rules via online questionnaires and revising
                      boundary rules based on questionnaire responses, and 4)
                      testing reliability of the protocol definitions on multiple
                      MRI datasets.ResultFor both the hippocampal body and head,
                      we have developed a preliminary subfield segmentation
                      protocol (i.e. completed steps 1‐2, see Figure 2 for a
                      histology slice segmented by three anatomists). Step 3 was
                      piloted for the outer boundaries of the body (i.e., the
                      anterior/posterior, medial/lateral, and superior/inferior
                      boundaries) using an online questionnaire describing each of
                      the proposed rules. 29 labs participated and consensus
                      agreement was reached for all rules, with only minor changes
                      being made to improve comprehension and clarity. We are now
                      creating and administering additional questionnaires for
                      assessing agreement of the hippocampal body and head inner
                      boundary rules (e.g., between the CA fields and dentate
                      gyrus). Upon completion of the assessment/revision process
                      for each set of rules, the final phase – reliability
                      testing of the protocol – should begin mid 2020 for the
                      body.ConclusionOnce completed, the harmonized protocol will
                      significantly facilitate cross‐study comparisons thus
                      advancing insight in the role of hippocampal subfields
                      across the lifespan in aging and disease.},
      cin          = {INM-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571)},
      pid          = {G:(DE-HGF)POF3-571},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1002/alz.046652},
      url          = {https://juser.fz-juelich.de/record/889131},
}