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000889188 1001_ $$0P:(DE-HGF)0$$aWeller, Anna$$b0$$eCorresponding author
000889188 245__ $$aFinding new communities: A principle of neuronal network reorganization in Alzheimer’s disease.
000889188 260__ $$aNew Rochelle, NY$$bLiebert$$c2021
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000889188 520__ $$aBackground: Graph-theoretical analyses have been previously used to investigate changes in the functional connectome in patients with Alzheimer's disease (AD). However, these analyses generally assume static organizational principles, thereby neglecting a fundamental reconfiguration of functional connections in the face of neurodegeneration.Methods: Here, we focus on differences in the community structure of the functional connectome in young and old individuals and patients with AD. Patients with AD, moreover, underwent molecular imaging positron emission tomography by using [18F]AV1451 to measure tau burden, a major hallmark of AD.Results: Although the overall organizational principles of the community structure of the human functional connectome were preserved even in advanced healthy aging, they were considerably changed in AD. We discovered that the communities in AD are re-organized, with nodes changing their allegiance to communities, thus resulting in an overall less efficient re-organized community structure. We further discovered that nodes with a tendency to leave the communities displayed a relatively higher tau pathology burden.Discussion: Together, this study suggests that local tau pathology in AD is associated to fundamental changes in basic organizational principles of the human connectome. Our results shed new light on previous findings obtained by using the graph theory in AD and imply a general principle of the brain in response to neurodegeneration.
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000889188 7001_ $$0P:(DE-Juel1)166265$$aBischof, Gérard Nisal$$b1
000889188 7001_ $$0P:(DE-Juel1)165597$$aSchlüter, Philipp$$b2
000889188 7001_ $$0P:(DE-Juel1)167565$$aRichter, Nils$$b3$$ufzj
000889188 7001_ $$0P:(DE-Juel1)162382$$aDronse, Julian$$b4
000889188 7001_ $$0P:(DE-Juel1)131736$$aOnur, Özgür$$b5
000889188 7001_ $$0P:(DE-Juel1)166419$$aNeumaier, Bernd$$b6
000889188 7001_ $$0P:(DE-Juel1)131730$$aKukolja, Juraj$$b7
000889188 7001_ $$0P:(DE-Juel1)131777$$aLangen, Karl-Josef$$b8
000889188 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon R.$$b9
000889188 7001_ $$0P:(DE-HGF)0$$aKunoth, Angela$$b10
000889188 7001_ $$0P:(DE-HGF)0$$aShao, Yaping$$b11
000889188 7001_ $$0P:(DE-Juel1)169110$$avan Eimeren, Thilo$$b12
000889188 7001_ $$0P:(DE-Juel1)177611$$aDrzezga, Alexander$$b13
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000889188 8564_ $$uhttps://juser.fz-juelich.de/record/889188/files/Weller__2020_BrainConnect_FindingNewCommunities_new_including_figures%20post%20print.pdf$$yPublished on 2021-04-13. Available in OpenAccess from 2022-04-13.
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