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@ARTICLE{Weller:889188,
      author       = {Weller, Anna and Bischof, Gérard Nisal and Schlüter,
                      Philipp and Richter, Nils and Dronse, Julian and Onur,
                      Özgür and Neumaier, Bernd and Kukolja, Juraj and Langen,
                      Karl-Josef and Fink, Gereon R. and Kunoth, Angela and Shao,
                      Yaping and van Eimeren, Thilo and Drzezga, Alexander},
      title        = {{F}inding new communities: {A} principle of neuronal
                      network reorganization in {A}lzheimer’s disease.},
      journal      = {Brain Connectivity},
      volume       = {11},
      number       = {3},
      issn         = {2158-0022},
      address      = {New Rochelle, NY},
      publisher    = {Liebert},
      reportid     = {FZJ-2021-00098},
      pages        = {225-238},
      year         = {2021},
      abstract     = {Background: Graph-theoretical analyses have been previously
                      used to investigate changes in the functional connectome in
                      patients with Alzheimer's disease (AD). However, these
                      analyses generally assume static organizational principles,
                      thereby neglecting a fundamental reconfiguration of
                      functional connections in the face of
                      neurodegeneration.Methods: Here, we focus on differences in
                      the community structure of the functional connectome in
                      young and old individuals and patients with AD. Patients
                      with AD, moreover, underwent molecular imaging positron
                      emission tomography by using [18F]AV1451 to measure tau
                      burden, a major hallmark of AD.Results: Although the overall
                      organizational principles of the community structure of the
                      human functional connectome were preserved even in advanced
                      healthy aging, they were considerably changed in AD. We
                      discovered that the communities in AD are re-organized, with
                      nodes changing their allegiance to communities, thus
                      resulting in an overall less efficient re-organized
                      community structure. We further discovered that nodes with a
                      tendency to leave the communities displayed a relatively
                      higher tau pathology burden.Discussion: Together, this study
                      suggests that local tau pathology in AD is associated to
                      fundamental changes in basic organizational principles of
                      the human connectome. Our results shed new light on previous
                      findings obtained by using the graph theory in AD and imply
                      a general principle of the brain in response to
                      neurodegeneration.},
      cin          = {INM-3 / INM-2 / INM-5 / INM-4},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-2-20090406 /
                      I:(DE-Juel1)INM-5-20090406 / I:(DE-Juel1)INM-4-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525) / 5254 - Neuroscientific
                      Data Analytics and AI (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253 / G:(DE-HGF)POF4-5254},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33356820},
      UT           = {WOS:000640690500007},
      doi          = {10.1089/brain.2020.0889},
      url          = {https://juser.fz-juelich.de/record/889188},
}