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@ARTICLE{Stickel:889303,
author = {Stickel, S. and Eickhoff, Simon and Habel, U. and
Stickeler, E. and Goecke, T. W. and Lang, J. and Chechko,
N.},
title = {{E}ndocrine stress response in pregnancy and 12 weeks
postpartum – {E}xploring risk factors for postpartum
depression},
journal = {Psychoneuroendocrinology},
volume = {125},
issn = {0306-4530},
address = {Amsterdam [u.a.]},
publisher = {Elsevier Science},
reportid = {FZJ-2021-00195},
pages = {105122},
year = {2021},
note = {This study was funded by the rotation program (2015–2017)
of the medical faculty of the University Hospital RWTH
Aachen, the Deutsche Forschungsgemeinschaft (German Research
Foundation, DFG, CH 1718/2-1) and the International Research
Training Group (IRTG 2150) of the DFG.},
abstract = {Pregnancy and the postpartum period are characterized by
physiological alterations in cortisol and cortisone levels.
In the present study, we sought to explore the risk factors
for postpartum depression (PPD) and self-remitting
postpartum adjustment disorder (AD) and whether
cortisol/cortisone metabolism might have any bearing on
them. Hair samples from 196 participants (mean age = 31.44,
SD = 4.71) were collected at two time points (1-6 days after
childbirth and 12 weeks postpartum) to determine the
cumulative hair cortisol (HCC) and hair cortisone (HCNC)
exposure in the third trimester and during the 12 weeks
postpartum. Compared to the non-depressed group (ND, n =
141), more women in the AD (n = 28) and PPD (n = 27) groups
had a personal or family history of depression and more
stressful life events. Compared to ND and PPD, more women in
the AD group had birth-related complications with their
children being more often transferred to a pediatric ward.
The factors associated with PPD were found to include being
unmarried and having a lower household income, less support
at home, more subjectively perceived stress after childbirth
and lower maternal sensitivity. The natural decrease in HCC
concentration from the third trimester to 12 weeks
postpartum was significant only in the ND and AD groups, but
not in PPD. In summary, prolonged subjectively perceived
postpartum stress associated with living situations may
contribute to the development of PPD while birth- and
child-related complications are likely to trigger brief
episodes of AD. Only in ND and AD, the pregnancy-related
physiological changes in glucocorticoid levels return to the
pre-pregnancy baseline after 12 weeks. Our observations
point to the difference between the ND and PPD groups in
glucocorticoid metabolism-related postpartum adjustment,
which may be a factor in the development of PPD.},
cin = {INM-7 / INM-10},
ddc = {610},
cid = {I:(DE-Juel1)INM-7-20090406 / I:(DE-Juel1)INM-10-20170113},
pnm = {525 - Decoding Brain Organization and Dysfunction
(POF4-525)},
pid = {G:(DE-HGF)POF4-525},
typ = {PUB:(DE-HGF)16},
pubmed = {33421704},
UT = {WOS:000621359000012},
doi = {10.1016/j.psyneuen.2020.105122},
url = {https://juser.fz-juelich.de/record/889303},
}