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@ARTICLE{Arasappan:889304,
      author       = {Arasappan, Dhivya and Eickhoff, Simon B. and Nemeroff,
                      Charles B. and Hofmann, Hans A. and Jabbi, Mbemba},
      title        = {{T}ranscription {F}actor {M}otifs {A}ssociated with
                      {A}nterior {I}nsula {G}ene {E}xpression {U}nderlying {M}ood
                      {D}isorder {P}henotypes},
      journal      = {Molecular neurobiology},
      volume       = {58},
      issn         = {1559-1182},
      address      = {Totowa, NJ},
      publisher    = {Humana Press},
      reportid     = {FZJ-2021-00196},
      pages        = {1978–1989},
      year         = {2021},
      note         = {This work was supported by the Dell Medical School, UT
                      Austin Mulva Neuroscience Clinics Startup funds for MJ; DA
                      and CBN are supported by the National Institutes of Health
                      (NIH) and HH is supported by NSF.The funding bodies nor any
                      other entities were involved in the design of the study and
                      collection, analysis, and interpretation of data presented
                      here.},
      abstract     = {Mood disorders represent a major cause of morbidity and
                      mortality worldwide but the brain-related molecular
                      pathophysiology in mood disorders remains largely undefined.
                      Because the anterior insula is reduced in volume in patients
                      with mood disorders, RNA was extracted from the anterior
                      insula postmortem anterior insula of mood disorder samples
                      and compared with unaffected controls for RNA-sequencing
                      identification of differentially expressed genes (DEGs) in
                      (a) bipolar disorder (BD; n = 37) versus (vs.) controls (n =
                      33), and (b) major depressive disorder (MDD n = 30) vs.
                      controls, and (c) low vs. high axis I comorbidity (a measure
                      of cumulative psychiatric disease burden). Given the
                      regulatory role of transcription factors (TFs) in gene
                      expression via specific-DNA-binding domains (motifs), we
                      used JASPAR TF binding database to identify TF-motifs. We
                      found that DEGs in BD vs. controls, MDD vs. controls, and
                      high vs. low axis I comorbidity were associated with
                      TF-motifs that are known to regulate expression of toll-like
                      receptor genes, cellular homeostatic-control genes, and
                      genes involved in embryonic, cellular/organ, and brain
                      development. Robust imaging-guided transcriptomics by using
                      meta-analytic imaging results to guide independent
                      postmortem dissection for RNA-sequencing was applied by
                      targeting the gray matter volume reduction in the anterior
                      insula in mood disorders, to guide independent postmortem
                      identification of TF motifs regulating DEG. Our findings of
                      TF-motifs that regulate the expression of immune, cellular
                      homeostatic-control, and developmental genes provide novel
                      information about the hierarchical relationship between gene
                      regulatory networks, the TFs that control them, and
                      proximate underlying neuroanatomical phenotypes in mood
                      disorders.},
      cin          = {INM-7},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33411239},
      UT           = {WOS:000605898700001},
      doi          = {10.1007/s12035-020-02195-8},
      url          = {https://juser.fz-juelich.de/record/889304},
}