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000889345 1001_ $$0P:(DE-Juel1)131810$$aBier, Dirk$$b0$$eCorresponding author
000889345 245__ $$aPreparation of 5-[131I]iodotubercidin for the detection of adenosine kinase
000889345 260__ $$aDordrecht [u.a.]$$bSpringer Science + Business Media B.V.$$c2020
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000889345 520__ $$a5-Iodotubercidin is a prototype adenosine kinase (AK) inhibitor with potent anti-seizure activity in rodent epilepsy models. Using the chloramine-T method for radioiodination of tubercidin with 131I, we prepared no-carrier-added 5-[131I]iodotubercidin (5-[131I]IT) in a radiochemical yield of 61 ± 13% and with a radiochemical purity of > 99% (molar activity = 10–40 GBq/µmol). In vitro competition and saturation experiments demonstrated specific binding of 5-[131I]IT in rodent brain slices (KD ~ 31 nM), but ex vivo autoradiography revealed its accumulation in cerebral vessels. We conclude that 5-[131I]IT could be a useful tool for the detection and quantification of AK in in vitro studies.
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000889345 7001_ $$0P:(DE-Juel1)131824$$aHolschbach, Marcus$$b1$$ufzj
000889345 7001_ $$0P:(DE-Juel1)131711$$aWedekind, Franziska$$b2$$ufzj
000889345 7001_ $$0P:(DE-HGF)0$$aSihver, Wiebke$$b3
000889345 7001_ $$0P:(DE-Juel1)131817$$aDrewes, Birte$$b4$$ufzj
000889345 7001_ $$0P:(DE-Juel1)131847$$aSchulze, Annette$$b5$$ufzj
000889345 7001_ $$0P:(DE-Juel1)175142$$aNeumaier, Felix$$b6$$ufzj
000889345 7001_ $$0P:(DE-Juel1)166419$$aNeumaier, Bernd$$b7$$ufzj
000889345 7001_ $$0P:(DE-Juel1)131672$$aBauer, Andreas$$b8$$ufzj
000889345 773__ $$0PERI:(DE-600)2017242-4$$a10.1007/s10967-020-07465-2$$gVol. 326, no. 3, p. 1691 - 1697$$n3$$p1691 - 1697$$tJournal of radioanalytical and nuclear chemistry$$v326$$x1588-2780$$y2020
000889345 8564_ $$uhttps://juser.fz-juelich.de/record/889345/files/Bier2020_Article_PreparationOf5-%5B131I%5Diodotuber.pdf
000889345 8564_ $$uhttps://juser.fz-juelich.de/record/889345/files/JRNC_Manuscript_Iodotubercidin_r1b.pdf$$yPublished on 2020-10-29. Available in OpenAccess from 2021-10-29.
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