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@ARTICLE{Bier:889345,
      author       = {Bier, Dirk and Holschbach, Marcus and Wedekind, Franziska
                      and Sihver, Wiebke and Drewes, Birte and Schulze, Annette
                      and Neumaier, Felix and Neumaier, Bernd and Bauer, Andreas},
      title        = {{P}reparation of 5-[131{I}]iodotubercidin for the detection
                      of adenosine kinase},
      journal      = {Journal of radioanalytical and nuclear chemistry},
      volume       = {326},
      number       = {3},
      issn         = {1588-2780},
      address      = {Dordrecht [u.a.]},
      publisher    = {Springer Science + Business Media B.V.},
      reportid     = {FZJ-2021-00234},
      pages        = {1691 - 1697},
      year         = {2020},
      abstract     = {5-Iodotubercidin is a prototype adenosine kinase (AK)
                      inhibitor with potent anti-seizure activity in rodent
                      epilepsy models. Using the chloramine-T method for
                      radioiodination of tubercidin with 131I, we prepared
                      no-carrier-added 5-[131I]iodotubercidin (5-[131I]IT) in a
                      radiochemical yield of $61 ± 13\%$ and with a
                      radiochemical purity of $> 99\%$ (molar
                      activity = 10–40 GBq/µmol). In vitro competition and
                      saturation experiments demonstrated specific binding of
                      5-[131I]IT in rodent brain slices (KD ~ 31 nM), but ex
                      vivo autoradiography revealed its accumulation in cerebral
                      vessels. We conclude that 5-[131I]IT could be a useful tool
                      for the detection and quantification of AK in in vitro
                      studies.},
      cin          = {INM-5 / INM-2},
      ddc          = {540},
      cid          = {I:(DE-Juel1)INM-5-20090406 / I:(DE-Juel1)INM-2-20090406},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000584877900006},
      doi          = {10.1007/s10967-020-07465-2},
      url          = {https://juser.fz-juelich.de/record/889345},
}