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@ARTICLE{Kolainac:889360,
      author       = {Kolašinac, Rejhana and Bier, Dirk and Schmitt, Laura and
                      Yabluchanskiy, Andriy and Neumaier, Bernd and Merkel, Rudolf
                      and Csiszár, Agnes},
      title        = {{D}elivery of the {R}adionuclide 131{I} {U}sing {C}ationic
                      {F}usogenic {L}iposomes as {N}anocarriers},
      journal      = {International journal of molecular sciences},
      volume       = {22},
      number       = {1},
      issn         = {1422-0067},
      address      = {Basel},
      publisher    = {Molecular Diversity Preservation International},
      reportid     = {FZJ-2021-00249},
      pages        = {457 -},
      year         = {2021},
      abstract     = {Liposomes are highly biocompatible and versatile drug
                      carriers with an increasing number of applications in the
                      field of nuclear medicine and diagnostics. So far, only
                      negatively charged liposomes with intercalated radiometals,
                      e.g., 64Cu, 99mTc, have been reported. However, the process
                      of cellular uptake of liposomes by endocytosis is rather
                      slow. Cellular uptake can be accelerated by recently
                      developed cationic liposomes, which exhibit extraordinarily
                      high membrane fusion ability. The aim of the present study
                      was the development of the formulation and the
                      characterization of such cationic fusogenic liposomes with
                      intercalated radioactive [131I]I− for potential use in
                      therapeutic applications. The epithelial human breast cancer
                      cell line MDA-MB-231 was used as a model for invasive cancer
                      cells and cellular uptake of [131I]I− was monitored in
                      vitro. Delivery efficiencies of cationic and neutral
                      liposomes were compared with uptake of free iodide. The best
                      cargo delivery efficiency $(~10\%)$ was achieved using
                      cationic fusogenic liposomes due to their special delivery
                      pathway of membrane fusion. Additionally, human blood cells
                      were also incubated with cationic control liposomes and free
                      [131I]I−. In these cases, iodide delivery efficiencies
                      remained below $3\%.$},
      cin          = {IBI-2 / INM-5},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IBI-2-20200312 / I:(DE-Juel1)INM-5-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525) / 5241 - Molecular
                      Information Processing in Cellular Systems (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5253 / G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33466417},
      UT           = {WOS:000606224300001},
      doi          = {10.3390/ijms22010457},
      url          = {https://juser.fz-juelich.de/record/889360},
}