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@ARTICLE{Rosjat:889398,
      author       = {Rosjat, Nils and Wang, Bingqing and Liu, Liqing and Fink,
                      Gereon R. and Daun, Silvia},
      title        = {{S}timulus transformation into motor action: dynamic graph
                      analysis reveals a posterior-to-anterior shift in brain
                      network communication of older subjects},
      volume       = {000},
      reportid     = {FZJ-2021-00275},
      pages        = {000},
      year         = {2020},
      abstract     = {Cognitive performance slows down with increasing age. This
                      includes cognitive processes that are essential for the
                      performance of a motor act, such as the slowing down in
                      response to an external stimulus. The objective of this
                      study was to identify aging-associated functional changes in
                      the brain networks that are involved in the transformation
                      of external stimuli into motor action. To investigate this
                      topic, we employed dynamic graphs based on phase-locking of
                      Electroencephalography signals recorded from healthy younger
                      and older subjects while performing a simple visually-cued
                      finger-tapping task. The network analysis yielded specific
                      age-related network structures varying in time in the low
                      frequencies (2-7 Hz), which are closely connected to
                      stimulus processing, movement initiation and execution in
                      both age groups. The networks in older subjects, however,
                      contained several additional, particularly interhemispheric,
                      connections and showed an overall increased coupling
                      density. Cluster analyses revealed reduced variability of
                      the subnetworks in older subjects, particularly during
                      movement preparation. In younger subjects, occipital,
                      parietal, sensorimotor and central regions were - temporally
                      arranged in this order - heavily involved in hub nodes.
                      Whereas in older subjects, a hub in frontal regions preceded
                      the noticeably delayed occurrence of sensorimotor hubs,
                      indicating different neural information processing in older
                      subjects.All observed changes in brain network organization,
                      which are based on neural synchronization in the low
                      frequencies, provide a possible neural mechanism underlying
                      previous fMRI data, which report an overactivation,
                      especially in the prefrontal and pre-motor areas, associated
                      with a loss of hemispheric lateralization in older
                      subjects.},
      cin          = {INM-3},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)25},
      doi          = {10.1101/2020.02.26.966325},
      url          = {https://juser.fz-juelich.de/record/889398},
}