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@ARTICLE{Habash:889647,
      author       = {Habash, Samer S. and Könen, Philipp P. and Loeschcke,
                      Anita and Wüst, Matthias and Jaeger, Karl-Erich and
                      Drepper, Thomas and Grundler, Florian M. W. and Schleker, A.
                      Sylvia S.},
      title        = {{T}he {P}lant {S}esquiterpene {N}ootkatone {E}fficiently
                      {R}educes {H}eterodera schachtii {P}arasitism by
                      {A}ctivating {P}lant {D}efense},
      journal      = {International journal of molecular sciences},
      volume       = {21},
      number       = {24},
      issn         = {1422-0067},
      address      = {Basel},
      publisher    = {Molecular Diversity Preservation International},
      reportid     = {FZJ-2021-00279},
      pages        = {9627 -},
      year         = {2020},
      abstract     = {Plant parasitic nematodes, including the beet cyst nematode
                      Heterodera schachtii, constitute a devastating problem for
                      crops worldwide. The limited availability of sustainable
                      management options illustrates the need for new eco-friendly
                      control means. Plant metabolites represent an invaluable
                      source of active compounds for the discovery of such novel
                      antagonistic agents. Here, we evaluated the impact of eight
                      plant terpenoids on the H. schachtii parasitism of
                      Arabidopsis thaliana. None of the metabolites affected the
                      plant development (5 or 10 ppm). Nootkatone decreased the
                      number of adult nematodes on A. thaliana to $50\%,$ with the
                      female nematodes being smaller compared to the control. In
                      contrast, three other terpenoids increased the parasitism
                      and/or female size. We discovered that nootkatone
                      considerably decreased the number of nematodes that
                      penetrated A. thaliana roots, but neither affected the
                      nematode viability or attraction to plant roots, nor
                      triggered the production of plant reactive oxygen species or
                      changed the plant’s sesquiterpene profile. However, we
                      demonstrated that nootkatone led to a significant
                      upregulation of defense-related genes involved in salicylic
                      and jasmonic acid pathways. Our results indicate that
                      nootkatone is a promising candidate to be developed into a
                      novel plant protection agent acting as a stimulator of plant
                      immunity against parasitic nematodes},
      cin          = {IMET},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IMET-20090612},
      pnm          = {583 - Innovative Synergisms (POF3-583)},
      pid          = {G:(DE-HGF)POF3-583},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33348829},
      UT           = {WOS:000602793200001},
      doi          = {10.3390/ijms21249627},
      url          = {https://juser.fz-juelich.de/record/889647},
}