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@ARTICLE{Geraets:889724,
      author       = {Geraets, James and Pothula, Karunakar R and Schröder,
                      Gunnar F},
      title        = {{I}ntegrating cryo-{EM} and {NMR} data},
      journal      = {Current opinion in structural biology},
      volume       = {61},
      issn         = {0959-440X},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2021-00345},
      pages        = {173 - 181},
      year         = {2020},
      abstract     = {Single-particle cryo-electron microscopy (cryo-EM) is
                      increasingly used as a technique to determine the atomic
                      structure of challenging biological systems. Recent advances
                      in microscope engineering, electron detection, and image
                      processing have allowed the structural determination of
                      bigger and more flexible targets than possible with the
                      complementary techniques X-ray crystallography and NMR
                      spectroscopy. However, there exist many biological targets
                      for which atomic resolution cannot be currently achieved
                      with cryo-EM, making unambiguous determination of the
                      protein structure impossible. Although determining the
                      structure of large biological systems using solely NMR is
                      often difficult, highly complementary experimental
                      atomic-level data for each molecule can be derived from the
                      spectra, and used in combination with cryo-EM data. We
                      review here strategies with which both techniques can be
                      synergistically combined, in order to reach detail and
                      understanding unattainable by each technique acting alone;
                      and the types of biological systems for which such an
                      approach would be desirable.},
      cin          = {IBI-7},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IBI-7-20200312},
      pnm          = {551 - Functional Macromolecules and Complexes (POF3-551)},
      pid          = {G:(DE-HGF)POF3-551},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {32028106},
      UT           = {WOS:000525828700024},
      doi          = {10.1016/j.sbi.2020.01.008},
      url          = {https://juser.fz-juelich.de/record/889724},
}