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@ARTICLE{Herz:889765,
      author       = {Herz, Damian M. and Meder, David and Camilleri, Julia and
                      Eickhoff, Simon B. and Siebner, Hartwig R.},
      title        = {{B}rain {M}otor {N}etwork {C}hanges in {P}arkinson's
                      {D}isease: {E}vidence from {M}eta‐{A}nalytic {M}odeling},
      journal      = {Movement disorders},
      volume       = {36},
      number       = {5},
      issn         = {1531-8257},
      address      = {New York, NY},
      publisher    = {Wiley},
      reportid     = {FZJ-2021-00379},
      pages        = {1180-1190},
      year         = {2021},
      abstract     = {Background: Motor-related brain activity in Parkinson's
                      disease has been investigated in a multitude of functional
                      neuroimaging studies, which often yielded apparently
                      conflicting results. Our previous meta-analysis did not
                      resolve inconsistencies regarding cortical activation
                      differences in Parkinson's disease, which might be related
                      to the limited number of studies that could be included.
                      Therefore, we conducted a revised meta-analysis including a
                      larger number of studies. The objectives of this study were
                      to elucidate brain areas that consistently show abnormal
                      motor-related activation in Parkinson's disease and to
                      reveal their functional connectivity profiles using
                      meta-analytic approaches.Methods: We applied a quantitative
                      meta-analysis of functional neuroimaging studies testing
                      limb movements in Parkinson's disease comprising data from
                      39 studies, of which 15 studies (285 of 571 individual
                      patients) were published after the previous meta-analysis.
                      We also conducted meta-analytic connectivity modeling to
                      elucidate the connectivity profiles of areas showing
                      abnormal activation.Results: We found consistent
                      motor-related underactivation of bilateral posterior putamen
                      and cerebellum in Parkinson's disease. Primary motor cortex
                      and the supplementary motor area also showed deficient
                      activation, whereas cortical regions localized directly
                      anterior to these areas expressed overactivation.
                      Connectivity modeling revealed that areas showing decreased
                      activation shared a common pathway through the posterior
                      putamen, whereas areas showing increased activation were
                      connected to the anterior putamen.Conclusions: Despite
                      conflicting results in individual neuroimaging studies, this
                      revised meta-analytic approach identified consistent
                      patterns of abnormal motor-related activation in Parkinson's
                      disease. The distinct patterns of decreased and increased
                      activity might be determined by their connectivity with
                      different subregions of the putamen. © 2021 The Authors.
                      Movement Disorders published by Wiley Periodicals LLC on
                      behalf of International Parkinson and Movement Disorder
                      Society.Keywords: Parkinson's disease; functional
                      neuroimaging; meta-analysis; motor.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {525 - Decoding Brain Organization and Dysfunction
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-525},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33427336},
      UT           = {WOS:000606519800001},
      doi          = {10.1002/mds.28468},
      url          = {https://juser.fz-juelich.de/record/889765},
}