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@ARTICLE{Rajkumar:889825,
      author       = {Rajkumar, Ravichandran and Régio Brambilla, Cláudia and
                      Veselinović, Tanja and Bierbrier, Joshua and Wyss,
                      Christine and Ramkiran, Shukti and Orth, Linda and Lang,
                      Markus and Rota Kops, Elena and Mauler, Jörg and Scheins,
                      Jürgen and Neumaier, Bernd and Ermert, Johannes and Herzog,
                      Hans and Langen, Karl-Josef and Binkofski, Ferdinand
                      Christoph and Lerche, Christoph and Shah, N. Jon and Neuner,
                      Irene},
      title        = {{E}xcitatory–inhibitory balance within {EEG} microstates
                      and resting-state f{MRI} networks: assessed via simultaneous
                      trimodal {PET}–{MR}–{EEG} imaging},
      journal      = {Translational Psychiatry},
      volume       = {11},
      number       = {1},
      issn         = {2158-3188},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {FZJ-2021-00438},
      pages        = {60},
      year         = {2021},
      abstract     = {The symbiosis of neuronal activities and glucose energy
                      metabolism is reflected in the generation of functional
                      magnetic resonance imaging (fMRI) and electroencephalography
                      (EEG) signals. However, their association with the balance
                      between neuronal excitation and inhibition (E/I-B), which is
                      closely related to the activities of glutamate and
                      γ-aminobutyric acid (GABA) and the receptor availability
                      (RA) of GABAA and mGluR5, remains unexplored. This research
                      investigates these associations during the resting state
                      (RS) condition using simultaneously recorded PET/MR/EEG
                      (trimodal) data. The trimodal data were acquired from three
                      studies using different radio-tracers such as, [11C]ABP688
                      (ABP) (N = 9), [11C]Flumazenil (FMZ) (N = 10) and
                      2-[18F]fluoro-2-deoxy-d-glucose (FDG) (N = 10) targeted
                      to study the mGluR5, GABAA receptors and glucose metabolism
                      respectively. Glucose metabolism and neuroreceptor binding
                      availability (non-displaceable binding potential (BPND)) of
                      GABAA and mGluR5 were found to be significantly higher and
                      closely linked within core resting-state networks (RSNs).
                      The neuronal generators of EEG microstates and the fMRI
                      measures were most tightly associated with the BPND of GABAA
                      relative to mGluR5 BPND and the glucose metabolism,
                      emphasising a predominance of inhibitory processes within in
                      the core RSNs at rest. Changes in the neuroreceptors leading
                      to an altered coupling with glucose metabolism may render
                      the RSNs vulnerable to psychiatric conditions. The paradigm
                      employed here will likely help identify the precise
                      neurobiological mechanisms behind these alterations in fMRI
                      functional connectivity and EEG oscillations, potentially
                      benefitting individualised healthcare treatment measures.},
      cin          = {INM-4 / INM-11 / JARA-BRAIN / INM-5},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-11-20170113 /
                      I:(DE-Juel1)VDB1046 / I:(DE-Juel1)INM-5-20090406},
      pnm          = {573 - Neuroimaging (POF3-573) / 5253 - Neuroimaging
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF3-573 / G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33462192},
      UT           = {WOS:000611941500001},
      doi          = {10.1038/s41398-020-01160-2},
      url          = {https://juser.fz-juelich.de/record/889825},
}