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@ARTICLE{Zhang:889870,
      author       = {Zhang, Yuting and Figueroa-Miranda, Gabriela and Wu,
                      Changtong and Willbold, Dieter and Offenhäusser, Andreas
                      and Mayer, Dirk},
      title        = {{E}lectrochemical dual-aptamer biosensors based on
                      nanostructured multielectrode arrays for the detection of
                      neuronal biomarkers},
      journal      = {Nanoscale},
      volume       = {12},
      number       = {31},
      issn         = {2040-3372},
      address      = {Cambridge},
      publisher    = {RSC Publ.},
      reportid     = {FZJ-2021-00478},
      pages        = {16501 - 16513},
      year         = {2020},
      note         = {Kein Post-print verfügbar},
      abstract     = {Multielectrode arrays (MEAs) have been increasingly used
                      for the development of biosensors due to their capability to
                      record signals from multiple channels, fast mass transfer
                      rates, and high spatial resolution. Alzheimer's disease (AD)
                      is often associated with mitochondrial dysfunction, which is
                      closely related to reduced levels of adenosine triphosphate
                      (ATP). Therefore, simultaneous detection of ATP together
                      with amyloid-β oligomers (AβO), a reliable biomarker for
                      AD, can potentially advance the early detection of
                      Alzheimer's disease. In this work, a dual-aptamer modified
                      MEA chip was developed that consists of microelectrodes
                      modified with electrodeposited 3D nanostructures (3D-GMEs).
                      Electrodeposition methods, deposition potential, and
                      deposition time were systematically altered and the active
                      surface areas as well as the electrode morphologies were
                      characterized by cyclic voltammetry and scanning electron
                      microscopy. The nanostructured microelectrodes were
                      sequentially modified with AβO and ATP specific aptamer
                      receptors. To achieve the modification of different aptamer
                      receptors at different 3D-GMEs of the same MEA chip,
                      electrochemical cleaning was applied to individual 3D-GMEs.
                      Ferrocene labels were attached to the aptamer receptors to
                      enable amperometric signaling after target–aptamer
                      binding. The developed aptasensor showed a linear detection
                      range from 1 pM to 200 nM for the detection of AβO and from
                      0.01 nM to 1000 nM for the detection of ATP. Finally, ATP
                      and AβO were detected simultaneously in the same analyte
                      solution by the same sensor chip, which could support the
                      early detection of AD, provide comprehensive information
                      about the health status of the patient, and be helpful for
                      pathological studies of neurodegenerative diseases.},
      cin          = {IBI-7},
      ddc          = {600},
      cid          = {I:(DE-Juel1)IBI-7-20200312},
      pnm          = {551 - Functional Macromolecules and Complexes (POF3-551)},
      pid          = {G:(DE-HGF)POF3-551},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {32729601},
      UT           = {WOS:000560178300009},
      doi          = {10.1039/D0NR03421E},
      url          = {https://juser.fz-juelich.de/record/889870},
}