000889879 001__ 889879
000889879 005__ 20220930130304.0
000889879 0247_ $$2doi$$a10.3390/ijms22010085
000889879 0247_ $$2ISSN$$a1422-0067
000889879 0247_ $$2ISSN$$a1661-6596
000889879 0247_ $$2Handle$$a2128/26895
000889879 0247_ $$2pmid$$a33374830
000889879 0247_ $$2WOS$$aWOS:000606050100001
000889879 037__ $$aFZJ-2021-00487
000889879 082__ $$a540
000889879 1001_ $$0P:(DE-Juel1)166320$$aSanwald, Julia L.$$b0
000889879 245__ $$aLack of GABARAP-Type Proteins Is Accompanied by Altered Golgi Morphology and Surfaceome Composition
000889879 260__ $$aBasel$$bMolecular Diversity Preservation International$$c2021
000889879 3367_ $$2DRIVER$$aarticle
000889879 3367_ $$2DataCite$$aOutput Types/Journal article
000889879 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1640941651_29763
000889879 3367_ $$2BibTeX$$aARTICLE
000889879 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000889879 3367_ $$00$$2EndNote$$aJournal Article
000889879 520__ $$aGABARAP (γ-aminobutyric acid type A receptor-associated protein) and its paralogues GABARAPL1 and GABARAPL2 comprise a subfamily of autophagy-related Atg8 proteins. They are studied extensively regarding their roles during autophagy. Originally, however, especially GABARAPL2 was discovered to be involved in intra-Golgi transport and homotypic fusion of post-mitotic Golgi fragments. Recently, a broader function of mammalian Atg8s on membrane trafficking through interaction with various soluble N-ethylmaleimide-sensitive factor-attachment protein receptors SNAREs was suggested. By immunostaining and microscopic analysis of the Golgi network, we demonstrate the importance of the presence of individual GABARAP-type proteins on Golgi morphology. Furthermore, triple knockout (TKO) cells lacking the whole GABARAP subfamily showed impaired Golgi-dependent vesicular trafficking as assessed by imaging of fluorescently labelled ceramide. With the Golgi apparatus being central within the secretory pathway, we sought to investigate the role of the GABARAP-type proteins for cell surface protein trafficking. By analysing the surfaceome compositionofTKOs, we identified a subset of cell surface proteins with altered plasma membrane localisation. Taken together, we provide novel insights into an underrated aspect of autophagy-independent functions of the GABARAP subfamily and recommend considering the potential impact of GABARAP subfamily proteins on a plethora of processes during experimental analysis of GABARAP-deficient cells not only in the autophagic context.
000889879 536__ $$0G:(DE-HGF)POF4-5241$$a5241 - Molecular Information Processing in Cellular Systems (POF4-524)$$cPOF4-524$$fPOF IV$$x0
000889879 588__ $$aDataset connected to CrossRef
000889879 7001_ $$0P:(DE-Juel1)171905$$aDobner, Jochen$$b1
000889879 7001_ $$0P:(DE-Juel1)168498$$aSimons, Indra M.$$b2
000889879 7001_ $$0P:(DE-HGF)0$$aPoschmann, Gereon$$b3
000889879 7001_ $$0P:(DE-HGF)0$$aStühler, Kai$$b4
000889879 7001_ $$0P:(DE-Juel1)181095$$aÜffing, Alina$$b5$$ufzj
000889879 7001_ $$0P:(DE-Juel1)132003$$aHoffmann, Silke$$b6
000889879 7001_ $$0P:(DE-Juel1)132029$$aWillbold, Dieter$$b7$$eCorresponding author
000889879 773__ $$0PERI:(DE-600)2019364-6$$a10.3390/ijms22010085$$gVol. 22, no. 1, p. 85 -$$n1$$p85 -$$tInternational journal of molecular sciences$$v22$$x1422-0067$$y2021
000889879 8564_ $$uhttps://juser.fz-juelich.de/record/889879/files/Invoice_MDPI_ijms-1010577_1567.54EUR.pdf
000889879 8564_ $$uhttps://juser.fz-juelich.de/record/889879/files/Lack%20of%20GABARAP-Type%20Proteins%20Is%20Accompanied%20by%20Altered%20Golgi%20Morphology%20and%20Surfaceome%20Composition.pdf$$yOpenAccess
000889879 8767_ $$81010577$$92020-12-22$$d2021-01-27$$eAPC$$jZahlung erfolgt$$pijms-10$$zFZJ-2020-05399, IBI-7 / Belegnr. 1200161715
000889879 909CO $$ooai:juser.fz-juelich.de:889879$$popenCost$$pVDB$$pdriver$$pOpenAPC$$popen_access$$popenaire$$pdnbdelivery
000889879 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)171905$$aForschungszentrum Jülich$$b1$$kFZJ
000889879 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)181095$$aForschungszentrum Jülich$$b5$$kFZJ
000889879 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)132003$$aForschungszentrum Jülich$$b6$$kFZJ
000889879 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)132029$$aForschungszentrum Jülich$$b7$$kFZJ
000889879 9131_ $$0G:(DE-HGF)POF4-524$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5241$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vMolecular and Cellular Information Processing$$x0
000889879 9141_ $$y2021
000889879 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2020-09-09
000889879 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2020-09-09
000889879 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000889879 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2020-09-09
000889879 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences$$d2020-09-09
000889879 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2020-09-09
000889879 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2020-09-09
000889879 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2020-09-09
000889879 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2020-09-09
000889879 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2020-09-09
000889879 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2020-09-09
000889879 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000889879 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2020-09-09
000889879 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2020-09-09
000889879 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bINT J MOL SCI : 2018$$d2020-09-09
000889879 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2020-09-09
000889879 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2020-09-09
000889879 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2020-09-09
000889879 920__ $$lyes
000889879 9201_ $$0I:(DE-Juel1)IBI-7-20200312$$kIBI-7$$lStrukturbiochemie$$x0
000889879 980__ $$ajournal
000889879 980__ $$aVDB
000889879 980__ $$aI:(DE-Juel1)IBI-7-20200312
000889879 980__ $$aAPC
000889879 980__ $$aUNRESTRICTED
000889879 9801_ $$aAPC
000889879 9801_ $$aFullTexts