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| 100 | 1 | _ | |a Sanwald, Julia L. |0 P:(DE-Juel1)166320 |b 0 |
| 245 | _ | _ | |a Lack of GABARAP-Type Proteins Is Accompanied by Altered Golgi Morphology and Surfaceome Composition |
| 260 | _ | _ | |a Basel |c 2021 |b Molecular Diversity Preservation International |
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| 520 | _ | _ | |a GABARAP (γ-aminobutyric acid type A receptor-associated protein) and its paralogues GABARAPL1 and GABARAPL2 comprise a subfamily of autophagy-related Atg8 proteins. They are studied extensively regarding their roles during autophagy. Originally, however, especially GABARAPL2 was discovered to be involved in intra-Golgi transport and homotypic fusion of post-mitotic Golgi fragments. Recently, a broader function of mammalian Atg8s on membrane trafficking through interaction with various soluble N-ethylmaleimide-sensitive factor-attachment protein receptors SNAREs was suggested. By immunostaining and microscopic analysis of the Golgi network, we demonstrate the importance of the presence of individual GABARAP-type proteins on Golgi morphology. Furthermore, triple knockout (TKO) cells lacking the whole GABARAP subfamily showed impaired Golgi-dependent vesicular trafficking as assessed by imaging of fluorescently labelled ceramide. With the Golgi apparatus being central within the secretory pathway, we sought to investigate the role of the GABARAP-type proteins for cell surface protein trafficking. By analysing the surfaceome compositionofTKOs, we identified a subset of cell surface proteins with altered plasma membrane localisation. Taken together, we provide novel insights into an underrated aspect of autophagy-independent functions of the GABARAP subfamily and recommend considering the potential impact of GABARAP subfamily proteins on a plethora of processes during experimental analysis of GABARAP-deficient cells not only in the autophagic context. |
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| 700 | 1 | _ | |a Dobner, Jochen |0 P:(DE-Juel1)171905 |b 1 |
| 700 | 1 | _ | |a Simons, Indra M. |0 P:(DE-Juel1)168498 |b 2 |
| 700 | 1 | _ | |a Poschmann, Gereon |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Stühler, Kai |0 P:(DE-HGF)0 |b 4 |
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| 700 | 1 | _ | |a Hoffmann, Silke |0 P:(DE-Juel1)132003 |b 6 |
| 700 | 1 | _ | |a Willbold, Dieter |0 P:(DE-Juel1)132029 |b 7 |e Corresponding author |
| 773 | _ | _ | |a 10.3390/ijms22010085 |g Vol. 22, no. 1, p. 85 - |0 PERI:(DE-600)2019364-6 |n 1 |p 85 - |t International journal of molecular sciences |v 22 |y 2021 |x 1422-0067 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/889879/files/Invoice_MDPI_ijms-1010577_1567.54EUR.pdf |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/889879/files/Lack%20of%20GABARAP-Type%20Proteins%20Is%20Accompanied%20by%20Altered%20Golgi%20Morphology%20and%20Surfaceome%20Composition.pdf |y OpenAccess |
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