% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Soloviov:889941,
      author       = {Soloviov, Dmytro and Cai, Yong Q. and Bolmatov, Dima and
                      Suvorov, Alexey and Zhernenkov, Kirill and Zav’yalov,
                      Dmitry and Bosak, Alexey and Uchiyama, Hiroshi and
                      Zhernenkov, Mikhail},
      title        = {{F}unctional lipid pairs as building blocks of
                      phase-separated membranes},
      journal      = {Proceedings of the National Academy of Sciences of the
                      United States of America},
      volume       = {117},
      number       = {9},
      issn         = {1091-6490},
      address      = {Washington, DC},
      publisher    = {National Acad. of Sciences},
      reportid     = {FZJ-2021-00547},
      pages        = {4749 - 4757},
      year         = {2020},
      abstract     = {Biological membranes exhibit a great deal of compositional
                      and phase heterogeneity due to hundreds of chemically
                      distinct components. As a result, phase separation processes
                      in cell membranes are extremely difficult to study,
                      especially at the molecular level. It is currently believed
                      that the lateral membrane heterogeneity and the formation of
                      domains, or rafts, are driven by lipid–lipid and
                      lipid–protein interactions. Nevertheless, the underlying
                      mechanisms regulating membrane heterogeneity remain poorly
                      understood. In the present work, we combine inelastic X-ray
                      scattering with molecular dynamics simulations to provide
                      direct evidence for the existence of strongly coupled
                      transient lipid pairs. These lipid pairs manifest themselves
                      experimentally through optical vibrational (a.k.a. phononic)
                      modes observed in binary
                      (1,2-dipalmitoyl-sn-glycero-3-phosphocholine
                      [DPPC]–cholesterol) and ternary
                      (DPPC–1,2-dioleoyl-sn-glycero-3-phosphocholine/1-palmitoyl-2-oleoyl-glycero-3-phosphocholine
                      [DOPC/POPC]–cholesterol) systems. The existence of a
                      phononic gap in these vibrational modes is a direct result
                      of the finite size of patches formed by these lipid pairs.
                      The observation of lipid pairs provides a spatial
                      (subnanometer) and temporal (subnanosecond) window into the
                      lipid–lipid interactions in complex mixtures of
                      saturated/unsaturated lipids and cholesterol. Our findings
                      represent a step toward understanding the lateral
                      organization and dynamics of membrane domains using a
                      well-validated probe with a high spatial and temporal
                      resolution.},
      cin          = {JCNS-FRM-II / JCNS-4 / MLZ / JCNS-2},
      ddc          = {500},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-4-20201012 / I:(DE-588b)4597118-3 /
                      I:(DE-Juel1)JCNS-2-20110106},
      pnm          = {6215 - Soft Matter, Health and Life Sciences (POF3-621) /
                      6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623)
                      / 6G15 - FRM II / MLZ (POF3-6G15)},
      pid          = {G:(DE-HGF)POF3-6215 / G:(DE-HGF)POF3-6G4 /
                      G:(DE-HGF)POF3-6G15},
      experiment   = {EXP:(DE-MLZ)MARIA-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {32071249},
      UT           = {WOS:000518473500048},
      doi          = {10.1073/pnas.1919264117},
      url          = {https://juser.fz-juelich.de/record/889941},
}