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@ARTICLE{Sochor:890018,
      author       = {Sochor, Benedikt and Düdükcü, Özgür and Lübtow,
                      Michael M. and Schummer, Bernhard and Jaksch, Sebastian and
                      Luxenhofer, Robert},
      title        = {{P}robing the {C}omplex {L}oading-{D}ependent {S}tructural
                      {C}hanges in {U}ltrahigh {D}rug-{L}oaded {P}olymer
                      {M}icelles by {S}mall-{A}ngle {N}eutron {S}cattering},
      journal      = {Langmuir},
      volume       = {36},
      number       = {13},
      issn         = {1520-5827},
      address      = {Washington, DC},
      publisher    = {ACS Publ.},
      reportid     = {FZJ-2021-00612},
      pages        = {3494 - 3503},
      year         = {2020},
      abstract     = {Drug-loaded polymer micelles or nanoparticles are being
                      continuously explored in the fields of drug delivery and
                      nanomedicine. Commonly, a simple core–shell structure is
                      assumed, in which the core incorporates the drug and the
                      corona provides steric shielding, colloidal stability, and
                      prevents protein adsorption. Recently, the interactions of
                      the dissolved drug with the micellar corona have received
                      increasing attention. Here, using small-angle neutron
                      scattering, we provide an in-depth study of the differences
                      in polymer micelle morphology of a small selection of
                      structurally closely related polymer micelles at different
                      loadings with the model compound curcumin. This work
                      supports a previous study using solid-state nuclear magnetic
                      resonance spectroscopy and we confirm that the drug resides
                      predominantly in the core of the micelle at low drug
                      loading. As the drug loading increases, neutron scattering
                      data suggests that an inner shell is formed, which we
                      interpret as the corona also starting to incorporate the
                      drug, whereas the outer shell mainly contains water and the
                      polymer. The presented data clearly shows that a better
                      understanding of the inner morphology and the impact of the
                      hydrophilic block can be important parameters for improved
                      drug loading in polymer micelles as well as provide insights
                      into the structure–property relationship.},
      cin          = {JCNS-FRM-II / MLZ / JCNS-1},
      ddc          = {540},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 / I:(DE-588b)4597118-3 /
                      I:(DE-Juel1)JCNS-1-20110106},
      pnm          = {632 - Materials – Quantum, Complex and Functional
                      Materials (POF4-632) / 6G4 - Jülich Centre for Neutron
                      Research (JCNS) (FZJ) (POF4-6G4)},
      pid          = {G:(DE-HGF)POF4-632 / G:(DE-HGF)POF4-6G4},
      experiment   = {EXP:(DE-MLZ)KWS1-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32203667},
      UT           = {WOS:000526391800022},
      doi          = {10.1021/acs.langmuir.9b03460},
      url          = {https://juser.fz-juelich.de/record/890018},
}