%0 Journal Article
%A Jamadar, Sharna D.
%A Ward, Phillip G. D.
%A Close, Thomas G.
%A Fornito, Alex
%A Premaratne, Malin
%A O’Brien, Kieran
%A Stäb, Daniel
%A Chen, Zhaolin
%A Shah, N. J.
%A Egan, Gary F.
%T Simultaneous BOLD-fMRI and constant infusion FDG-PET data of the resting human brain
%J Scientific data
%V 7
%N 1
%@ 2052-4463
%C London
%I Nature Publ. Group
%M FZJ-2021-00815
%P 363
%D 2020
%X Simultaneous [18 F]-fluorodeoxyglucose positron emission tomography and functional magnetic resonance imaging (FDG-PET/fMRI) provides the capability to image two sources of energetic dynamics in the brain – cerebral glucose uptake and the cerebrovascular haemodynamic response. Resting-state fMRI connectivity has been enormously useful for characterising interactions between distributed brain regions in humans. Metabolic connectivity has recently emerged as a complementary measure to investigate brain network dynamics. Functional PET (fPET) is a new approach for measuring FDG uptake with high temporal resolution and has recently shown promise for assessing the dynamics of neural metabolism. Simultaneous fMRI/fPET is a relatively new hybrid imaging modality, with only a few biomedical imaging research facilities able to acquire FDG PET and BOLD fMRI data simultaneously. We present data for n = 27 healthy young adults (18–20 yrs) who underwent a 95-min simultaneous fMRI/fPET scan while resting with their eyes open. This dataset provides significant re-use value to understand the neural dynamics of glucose metabolism and the haemodynamic response, the synchrony, and interaction between these measures, and the development of new single- and multi-modality image preparation and analysis procedures.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ 33087725
%U <Go to ISI:>//WOS:000585253900005
%R 10.1038/s41597-020-00699-5
%U https://juser.fz-juelich.de/record/890228