TY  - JOUR
AU  - Jamadar, Sharna D.
AU  - Ward, Phillip G. D.
AU  - Close, Thomas G.
AU  - Fornito, Alex
AU  - Premaratne, Malin
AU  - O’Brien, Kieran
AU  - Stäb, Daniel
AU  - Chen, Zhaolin
AU  - Shah, N. J.
AU  - Egan, Gary F.
TI  - Simultaneous BOLD-fMRI and constant infusion FDG-PET data of the resting human brain
JO  - Scientific data
VL  - 7
IS  - 1
SN  - 2052-4463
CY  - London
PB  - Nature Publ. Group
M1  - FZJ-2021-00815
SP  - 363
PY  - 2020
AB  - Simultaneous [18 F]-fluorodeoxyglucose positron emission tomography and functional magnetic resonance imaging (FDG-PET/fMRI) provides the capability to image two sources of energetic dynamics in the brain – cerebral glucose uptake and the cerebrovascular haemodynamic response. Resting-state fMRI connectivity has been enormously useful for characterising interactions between distributed brain regions in humans. Metabolic connectivity has recently emerged as a complementary measure to investigate brain network dynamics. Functional PET (fPET) is a new approach for measuring FDG uptake with high temporal resolution and has recently shown promise for assessing the dynamics of neural metabolism. Simultaneous fMRI/fPET is a relatively new hybrid imaging modality, with only a few biomedical imaging research facilities able to acquire FDG PET and BOLD fMRI data simultaneously. We present data for n = 27 healthy young adults (18–20 yrs) who underwent a 95-min simultaneous fMRI/fPET scan while resting with their eyes open. This dataset provides significant re-use value to understand the neural dynamics of glucose metabolism and the haemodynamic response, the synchrony, and interaction between these measures, and the development of new single- and multi-modality image preparation and analysis procedures.
LB  - PUB:(DE-HGF)16
C6  - 33087725
UR  - <Go to ISI:>//WOS:000585253900005
DO  - DOI:10.1038/s41597-020-00699-5
UR  - https://juser.fz-juelich.de/record/890228
ER  -