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@ARTICLE{Scarpazza:890316,
      author       = {Scarpazza, Cristina and Finos, Livio and Genon, Sarah and
                      Masiero, Laura and Bortolato, Elena and Cavaliere, Camilla
                      and Pezzaioli, Jessica and Monaro, Merylin and Navarin,
                      Nicolò and Battaglia, Umberto and Pietrini, Pietro and
                      Ferracuti, Stefano and Sartori, Giuseppe and Camperio Ciani,
                      Andrea S.},
      title        = {{I}diopathic and acquired pedophilia as two distinct
                      disorders: an insight from neuroimaging},
      journal      = {Brain imaging and behavior},
      volume       = {15},
      issn         = {1931-7565},
      address      = {New York, NY [u.a.]},
      publisher    = {Springer},
      reportid     = {FZJ-2021-00889},
      pages        = {2681–2692},
      year         = {2021},
      abstract     = {Pedophilia is a disorder of public concern because of its
                      association with child sexual offense and recidivism.
                      Previous neuroimagingstudies of potential brain
                      abnormalities underlying pedophilic behavior, either in
                      idiopathic or acquired (i.e., emergingfollowing brain
                      damages) pedophilia, led to inconsistent results. This study
                      sought to explore the neural underpinnings ofpedophilic
                      behavior and to determine the extent to which brain
                      alterations may be related to distinct psychopathological
                      featuresin pedophilia. To this aim, we run a coordinate
                      based meta-analysis on previously published papers reporting
                      whole brainanalysis and a lesion network analysis, using
                      brain lesions as seeds in a resting state connectivity
                      analysis. The behavioralprofiling approach was applied to
                      link identified regions with the corresponding psychological
                      processes. While no consistentneuroanatomical alterations
                      were identified in idiopathic pedophilia, the current
                      results support that all the lesions causingacquired
                      pedophilia are localized within a shared resting state
                      network that included posterior midlines structures, right
                      inferiortemporal gyrus and bilateral orbitofrontal cortex.
                      These regions are associated with action inhibition and
                      social cognition, abilitiesthat are consistently and
                      severely impaired in acquired pedophiles. This study
                      suggests that idiopathic and acquired pedophiliamay be two
                      distinct disorders, in line with their distinctive clinical
                      features, including age of onset, reversibility and
                      modusoperandi. Understanding the neurobiological
                      underpinnings of pedophilic behavior may contribute to a
                      more comprehensivecharacterization of these individuals on a
                      clinical ground, a pivotal step forward for the development
                      of more efficient therapeuticrehabilitation strategies.},
      cin          = {INM-7},
      ddc          = {150},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {525 - Decoding Brain Organization and Dysfunction
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-525},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33507519},
      UT           = {WOS:000612595300001},
      doi          = {10.1007/s11682-020-00442-z},
      url          = {https://juser.fz-juelich.de/record/890316},
}