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000890355 1001_ $$00000-0002-5662-9866$$aPapagiannopoulos, Aristeidis$$b0$$eCorresponding author
000890355 245__ $$aLamellarity and size distributions in mixed DPPC/amphiphilic poly(2-oxazoline) gradient copolymer vesicles and their temperature response
000890355 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2021
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000890355 520__ $$aMixed liposomes of dipalmitoylphosphatidylcholine (DPPC) and gradient (pseudodiblock) poly(2-methyl-2-oxazoline)-grad-poly(2-phenyl-2-oxazoline) (MPOx) copolymers are investigated by small angle neutron scattering (SANS). All experimental data, from different phospholipid-copolymer compositions, concentrations and temperatures are fitted with one model. This model allows the determination of the separate contributions from vesicular populations of different lamellarity and size. MPOx copolymers are proved to modify both the size and lamellarity of DPPC liposomes. The gradient copolymer with higher hydrophilic content induces shrinkage of the uni- and bi-lamellar DPPC vesicles. The copolymer with lower hydrophilic content causes dramatic changes on the lamellarity of DPPC vesicles by the formation of hexa-lamellar vesicles. The tendency of multi-lamellar vesicles to transform into uni-lamellar ones as temperature increases is more pronounced in the presence of the copolymers. These findings may have direct implications on the drug loading and release properties of liposomes and their interactions with cells.
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000890355 7001_ $$0P:(DE-HGF)0$$aDemetzos, Costas$$b2
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000890355 773__ $$0PERI:(DE-600)1496839-3$$a10.1016/j.chemphyslip.2020.105008$$gVol. 234, p. 105008 -$$p105008$$tChemistry and physics of lipids$$v234$$x0009-3084$$y2021
000890355 8564_ $$uhttps://juser.fz-juelich.de/record/890355/files/1-s2.0-S0009308420301390-main.pdf
000890355 8564_ $$uhttps://juser.fz-juelich.de/record/890355/files/DPPC-MPOx_CSB_10_rev.pdf$$yPublished on 2020-11-09. Available in OpenAccess from 2021-11-09.
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