TY  - JOUR
AU  - Papagiannopoulos, Aristeidis
AU  - Pippa, Natassa
AU  - Demetzos, Costas
AU  - Pispas, Stergios
AU  - Radulescu, Aurel
TI  - Lamellarity and size distributions in mixed DPPC/amphiphilic poly(2-oxazoline) gradient copolymer vesicles and their temperature response
JO  - Chemistry and physics of lipids
VL  - 234
SN  - 0009-3084
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - FZJ-2021-00900
SP  - 105008
PY  - 2021
AB  - Mixed liposomes of dipalmitoylphosphatidylcholine (DPPC) and gradient (pseudodiblock) poly(2-methyl-2-oxazoline)-grad-poly(2-phenyl-2-oxazoline) (MPOx) copolymers are investigated by small angle neutron scattering (SANS). All experimental data, from different phospholipid-copolymer compositions, concentrations and temperatures are fitted with one model. This model allows the determination of the separate contributions from vesicular populations of different lamellarity and size. MPOx copolymers are proved to modify both the size and lamellarity of DPPC liposomes. The gradient copolymer with higher hydrophilic content induces shrinkage of the uni- and bi-lamellar DPPC vesicles. The copolymer with lower hydrophilic content causes dramatic changes on the lamellarity of DPPC vesicles by the formation of hexa-lamellar vesicles. The tendency of multi-lamellar vesicles to transform into uni-lamellar ones as temperature increases is more pronounced in the presence of the copolymers. These findings may have direct implications on the drug loading and release properties of liposomes and their interactions with cells.
LB  - PUB:(DE-HGF)16
C6  - 33181095
UR  - <Go to ISI:>//WOS:000604900300003
DO  - DOI:10.1016/j.chemphyslip.2020.105008
UR  - https://juser.fz-juelich.de/record/890355
ER  -