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@ARTICLE{Papagiannopoulos:890355,
      author       = {Papagiannopoulos, Aristeidis and Pippa, Natassa and
                      Demetzos, Costas and Pispas, Stergios and Radulescu, Aurel},
      title        = {{L}amellarity and size distributions in mixed
                      {DPPC}/amphiphilic poly(2-oxazoline) gradient copolymer
                      vesicles and their temperature response},
      journal      = {Chemistry and physics of lipids},
      volume       = {234},
      issn         = {0009-3084},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2021-00900},
      pages        = {105008},
      year         = {2021},
      abstract     = {Mixed liposomes of dipalmitoylphosphatidylcholine (DPPC)
                      and gradient (pseudodiblock)
                      poly(2-methyl-2-oxazoline)-grad-poly(2-phenyl-2-oxazoline)
                      (MPOx) copolymers are investigated by small angle neutron
                      scattering (SANS). All experimental data, from different
                      phospholipid-copolymer compositions, concentrations and
                      temperatures are fitted with one model. This model allows
                      the determination of the separate contributions from
                      vesicular populations of different lamellarity and size.
                      MPOx copolymers are proved to modify both the size and
                      lamellarity of DPPC liposomes. The gradient copolymer with
                      higher hydrophilic content induces shrinkage of the uni- and
                      bi-lamellar DPPC vesicles. The copolymer with lower
                      hydrophilic content causes dramatic changes on the
                      lamellarity of DPPC vesicles by the formation of
                      hexa-lamellar vesicles. The tendency of multi-lamellar
                      vesicles to transform into uni-lamellar ones as temperature
                      increases is more pronounced in the presence of the
                      copolymers. These findings may have direct implications on
                      the drug loading and release properties of liposomes and
                      their interactions with cells.},
      cin          = {JCNS-FRM-II / MLZ / JCNS-1 / JCNS-4},
      ddc          = {530},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 / I:(DE-588b)4597118-3 /
                      I:(DE-Juel1)JCNS-1-20110106 / I:(DE-Juel1)JCNS-4-20201012},
      pnm          = {6G4 - Jülich Centre for Neutron Research (JCNS) (FZJ)
                      (POF4-6G4)},
      pid          = {G:(DE-HGF)POF4-6G4},
      experiment   = {EXP:(DE-MLZ)KWS2-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33181095},
      UT           = {WOS:000604900300003},
      doi          = {10.1016/j.chemphyslip.2020.105008},
      url          = {https://juser.fz-juelich.de/record/890355},
}