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@ARTICLE{Valero:890356,
      author       = {Valero, Margarita and Hu, Wenjing and Houston, Judith and
                      Dreiss, Cécile A.},
      title        = {{S}olubilisation of salicylate in {F}127 micelles: {E}ffect
                      of p{H} and temperature on morphology and interactions with
                      cyclodextrin},
      journal      = {Journal of molecular liquids},
      volume       = {322},
      issn         = {0167-7322},
      address      = {New York, NY [u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2021-00901},
      pages        = {114892},
      year         = {2021},
      abstract     = {The present work examines the behavior of salicylic acid
                      (SAL)-loaded F127 micelles as drug nanocarriers for
                      controlled release by means of interaction with
                      2,6-dimethyl-β-cyclodextrin (DIMEB) in the intestine at
                      basic pH = 7–8, both important excipients, of
                      pharmaceutical formulations.The results show that acidic pH
                      (pH = 1) strongly increases the partitioning of SAL in F127
                      micelles compared to neutral pH, due to the drug being in
                      its molecular form. Fluorescence spectroscopy and
                      small-angle neutron scattering show that free and SAL-loaded
                      F127 micelles transition to cylindrical micelles at pH = 1
                      and high temperatures (37 °C). Micelles loaded with SAL are
                      disrupted by DIMEB to a higher extent than at pH = 7 at
                      physiological temperature. This study reveals that F127
                      could be a valuable nanocarrier for intestine controlled
                      release of SAL. Taken together, our results highlight the
                      importance of water in the structure of the micelles and
                      their interaction with DIMEB, and bring precious insights
                      into the mechanisms that regulate drug loading and release
                      in complex formulations.},
      cin          = {JCNS-FRM-II / MLZ / JCNS-1 / JCNS-4},
      ddc          = {540},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 / I:(DE-588b)4597118-3 /
                      I:(DE-Juel1)JCNS-1-20110106 / I:(DE-Juel1)JCNS-4-20201012},
      pnm          = {6G4 - Jülich Centre for Neutron Research (JCNS) (FZJ)
                      (POF4-6G4)},
      pid          = {G:(DE-HGF)POF4-6G4},
      experiment   = {EXP:(DE-MLZ)KWS2-20140101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000610834000080},
      doi          = {10.1016/j.molliq.2020.114892},
      url          = {https://juser.fz-juelich.de/record/890356},
}