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@ARTICLE{PuigRigall:890359,
      author       = {Puig-Rigall, Joan and Blanco-Prieto, María J. and Aydillo,
                      Carlos and Radulescu, Aurel and Molero-Vilchez, Dolores and
                      Dreiss, Cécile A. and González-Gaitano, Gustavo},
      title        = {{P}oloxamine/{D}-α-{T}ocopheryl polyethylene glycol
                      succinate ({TPGS}) mixed micelles and gels: {M}orphology,
                      loading capacity and skin drug permeability},
      journal      = {Journal of molecular liquids},
      volume       = {324},
      issn         = {0167-7322},
      address      = {New York, NY [u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2021-00904},
      pages        = {114930},
      year         = {2021},
      abstract     = {The combination of polymeric surfactants with different
                      features into mixed micelles give access to properties that
                      may be superior to the single-component micelles. In this
                      work, we investigated synergistic effects in mixtures of
                      D-α-Tocopheryl polyethylene glycol succinate (TPGS) with
                      poloxamines (also known as Tetronic), pH-responsive and
                      thermogelling polyethylene oxide (PEO)-polypropylene oxide
                      (PPO) 4-arm block copolymers. We examined the morphology of
                      the self-assembled micelles of TPGS with Tetronic 1107
                      (T1107) and 908 (T908) in the presence of naproxen (NA),
                      used as a model drug, and assessed the capacity of the
                      single and mixed micelles to trap the guest, using a
                      combination of small-angle neutron scattering (SANS) and NMR
                      spectroscopy (1D, 2D-NOESY and diffusion NMR), over a range
                      of compositions and temperatures, in the dilute regime and
                      gel state. NA did not interact with T1107 or T908 in their
                      unimer form, but it was incorporated into the hydrophobic
                      core of the micelles above the critical micellar temperature
                      (CMT). In contrast, TPGS dissolved NA at any temperature,
                      mainly in the tocopherol core, with some partitioning in the
                      PEG-shell. The micellar structure was not altered by the
                      presence of NA, except for an expansion of the core size, a
                      result of the preferential accumulation of NA in that
                      compartment. The solubility of the drug in single component
                      micelles increased markedly with temperature, while mixed
                      micelles produced an intermediate enhancement of the
                      solubility between that of TPGS and the poloxamines, which
                      increased at higher TPGS/poloxamine ratios. Micellar
                      hydrogels formed by the packing of the polymeric mixed
                      micelles in a BCC macrolattice, whose structure was not
                      altered by the presence of the drug (at least at 0.2
                      $wt\%).$ The applicability of the drug-loaded gels for
                      topical formulations was explored by transdermal diffusion
                      testing using a synthetic model of skin, showing that the
                      diffusion of NA across the membrane was enhanced by
                      incorporating small amounts of TPGS to the hydrogel,
                      especially with the more hydrophilic T908.},
      cin          = {JCNS-FRM-II / MLZ},
      ddc          = {540},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 / I:(DE-588b)4597118-3},
      pnm          = {6G4 - Jülich Centre for Neutron Research (JCNS) (FZJ)
                      (POF4-6G4)},
      pid          = {G:(DE-HGF)POF4-6G4},
      experiment   = {EXP:(DE-MLZ)KWS2-20140101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000632343700086},
      doi          = {10.1016/j.molliq.2020.114930},
      url          = {https://juser.fz-juelich.de/record/890359},
}