TY  - JOUR
AU  - Kanellopoulos, Alexandros K.
AU  - Mariano, Vittoria
AU  - Spinazzi, Marco
AU  - Woo, Young Jae
AU  - McLean, Colin
AU  - Pech, Ulrike
AU  - Li, Ka Wan
AU  - Armstrong, J. Douglas
AU  - Giangrande, Angela
AU  - Callaerts, Patrick
AU  - Smit, August B.
AU  - Abrahams, Brett S.
AU  - Fiala, Andre
AU  - Achsel, Tilmann
AU  - Bagni, Claudia
TI  - Aralar Sequesters GABA into Hyperactive Mitochondria, Causing Social Behavior Deficits
JO  - Cell
VL  - 180
IS  - 6
SN  - 0092-8674
CY  - New York, NY
PB  - Elsevier
M1  - FZJ-2021-00927
SP  - 1178 - 1197.e20
PY  - 2020
AB  - Social impairment is frequently associated with mitochondrial dysfunction and altered neurotransmission. Although mitochondrial function is crucial for brain homeostasis, it remains unknown whether mitochondrial disruption contributes to social behavioral deficits. Here, we show that Drosophila mutants in the homolog of the human CYFIP1, a gene linked to autism and schizophrenia, exhibit mitochondrial hyperactivity and altered group behavior. We identify the regulation of GABA availability by mitochondrial activity as a biologically relevant mechanism and demonstrate its contribution to social behavior. Specifically, increased mitochondrial activity causes gamma aminobutyric acid (GABA) sequestration in the mitochondria, reducing GABAergic signaling and resulting in social deficits. Pharmacological and genetic manipulation of mitochondrial activity or GABA signaling corrects the observed abnormalities. We identify Aralar as the mitochondrial transporter that sequesters GABA upon increased mitochondrial activity. This study increases our understanding of how mitochondria modulate neuronal homeostasis and social behavior under physiopathological conditions.
LB  - PUB:(DE-HGF)16
C6  - 32200800
UR  - <Go to ISI:>//WOS:000520925300014
DO  - DOI:10.1016/j.cell.2020.02.044
UR  - https://juser.fz-juelich.de/record/890394
ER  -