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@ARTICLE{Coenen:890421,
      author       = {Coenen, Heinrich Hubert and Ermert, Johannes},
      title        = {{E}xpanding {PET}-applications in life sciences with
                      positron-emitters beyond fluorine-18},
      journal      = {Nuclear medicine and biology},
      volume       = {92},
      issn         = {0969-8051},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2021-00941},
      pages        = {241–269},
      year         = {2021},
      abstract     = {Positron emission tomography (PET) has become an
                      indispensable diagnostic tool in modern nuclear medical
                      diagnostics. Its outstanding molecular imaging features
                      allow repetitive studies on one individual and with high
                      sensitivity, though no interference. Rather few positron
                      emitters with near favourable physical properties, i.e.
                      carbon-11 and fluorine-18, furnished most studies in the
                      beginning, preferably if covalently bound as isotopic label
                      of small molecules. With the advancement of PET-devices the
                      scope of in vivo research in life sciences and especially
                      that of medical applications expanded, and other than
                      “standard” PET-nuclides received increasing
                      significance, like the radiometals copper-64 and gallium-68.
                      Especially during the last decades, positron emitters of
                      other chemical elements have gotten into the focus of
                      interest, concomitant with the technical advancements in
                      imaging and radionuclide production. With known nuclear
                      imaging properties and main production methods of emerging
                      positron emitters their usefulness for medical application
                      is promising and even proven for several ones already.
                      Unfortunate decay properties could be corrected for, and
                      β+-emitters, especially with a longer half-life, provided
                      new possibilities for application where slower processes are
                      of importance.Further on, (bio)chemical features of positron
                      emitters of other elements, among there many metals, not
                      only expanded the field of classical clinical
                      investigations, but also opened up new fields of
                      application. Appropriately labelled peptides, proteins and
                      nanoparticles lend itself as newer probes for PET-imaging,
                      e.g. in theragnostic or PET/MR hybrid imaging. Furthermore,
                      the potential of non-destructive in-vivo imaging with
                      positron emission tomography directs the view on further
                      areas of life sciences. Thus, exploiting the excellent
                      methodology for basic research on molecular biochemical
                      functions and processes is increasingly encouraged as well
                      in areas outside of health, such as plant and environmental
                      sciences.},
      cin          = {INM-5},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-5-20090406},
      pnm          = {525 - Decoding Brain Organization and Dysfunction
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-525},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {32900582},
      UT           = {WOS:000616652500023},
      doi          = {10.1016/j.nucmedbio.2020.07.003},
      url          = {https://juser.fz-juelich.de/record/890421},
}