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@ARTICLE{Goulas:890482,
      author       = {Goulas, A. and Changeux, J. P. and Wagstyl, K. and Amunts,
                      Katrin and Palomero-Gallagher, Nicola and Hilgetag, C. C.},
      title        = {{T}he natural axis of transmitter receptor distribution in
                      the human cerebral cortex},
      journal      = {Proceedings of the National Academy of Sciences of the
                      United States of America},
      volume       = {118},
      number       = {3},
      issn         = {0027-8424},
      address      = {Washington, DC},
      publisher    = {National Acad. of Sciences},
      reportid     = {FZJ-2021-00990},
      pages        = {e2020574118},
      year         = {2021},
      abstract     = {Transmitter receptors constitute a key component of the
                      molecular machinery for intercellular communication in the
                      brain. Recent efforts have mapped the density of diverse
                      transmitter receptors across the human cerebral cortex with
                      an unprecedented level of detail. Here, we distill these
                      observations into key organizational principles. We
                      demonstrate that receptor densities form a natural axis in
                      the human cerebral cortex, reflecting decreases in
                      differentiation at the level of laminar organization and a
                      sensory-to-association axis at the functional level. Along
                      this natural axis, key organizational principles are
                      discerned: progressive molecular diversity (increase of the
                      diversity of receptor density); excitation/inhibition
                      (increase of the ratio of excitatory-to-inhibitory receptor
                      density); and mirrored, orderly changes of the density of
                      ionotropic and metabotropic receptors. The uncovered natural
                      axis formed by the distribution of receptors aligns with the
                      axis that is formed by other dimensions of cortical
                      organization, such as the myelo- and cytoarchitectonic
                      levels. Therefore, the uncovered natural axis constitutes a
                      unifying organizational feature linking multiple dimensions
                      of the cerebral cortex, thus bringing order to the
                      heterogeneity of cortical organization.},
      cin          = {INM-1},
      ddc          = {500},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {525 - Decoding Brain Organization and Dysfunction
                      (POF4-525) / HBP SGA1 - Human Brain Project Specific Grant
                      Agreement 1 (720270) / HBP SGA2 - Human Brain Project
                      Specific Grant Agreement 2 (785907) / HBP SGA3 - Human Brain
                      Project Specific Grant Agreement 3 (945539)},
      pid          = {G:(DE-HGF)POF4-525 / G:(EU-Grant)720270 /
                      G:(EU-Grant)785907 / G:(EU-Grant)945539},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33452137},
      UT           = {WOS:000609633900066},
      doi          = {10.1073/pnas.2020574118},
      url          = {https://juser.fz-juelich.de/record/890482},
}