%0 Journal Article
%A Zaragori, Timothée
%A Castello, Angelo
%A Guedj, Eric
%A Girard, Antoine
%A Galldiks, Norbert
%A Albert, Nathalie L.
%A Lopci, Egesta
%A Verger, Antoine
%T Photopenic Defects in Gliomas With Amino-Acid PET and Relative Prognostic Value
%J Clinical nuclear medicine
%V 46
%N 1
%@ 1536-0229
%C [S.l.]
%I Ovid
%M FZJ-2021-00991
%P e36 - e37
%D 2021
%X The aim is to explore the concept of photopenic defects in newly diagnosed glioma patients with the 2 widely used 11C-MET and 18F-FDOPA PET amino acid tracers. Thirty-two 11C-MET and 26 18F-FDOPA PET scans with amino acid PET-negative gliomas were selected in this European multicentric study. Of these gliomas, 16 11C-MET and 10 18F-FDOPA PET scans with photopenic defects were identified, exhibiting lower mean tumor-to-background ratio as compared with isometabolic gliomas (P < 0.001). Gliomas with photopenic defects had no different progression-free survival than isometabolic gliomas in the whole population (P = 0.40), but shorter progression-free survival in the subgroup of World Health Organization grade II IDH-mutant astrocytomas (35 vs 68 months; P = 0.047).
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:32804767
%U <Go to ISI:>//WOS:000600422200022
%R 10.1097/RLU.0000000000003240
%U https://juser.fz-juelich.de/record/890483