TY  - JOUR
AU  - Zaragori, Timothée
AU  - Castello, Angelo
AU  - Guedj, Eric
AU  - Girard, Antoine
AU  - Galldiks, Norbert
AU  - Albert, Nathalie L.
AU  - Lopci, Egesta
AU  - Verger, Antoine
TI  - Photopenic Defects in Gliomas With Amino-Acid PET and Relative Prognostic Value
JO  - Clinical nuclear medicine
VL  - 46
IS  - 1
SN  - 1536-0229
CY  - [S.l.]
PB  - Ovid
M1  - FZJ-2021-00991
SP  - e36 - e37
PY  - 2021
AB  - The aim is to explore the concept of photopenic defects in newly diagnosed glioma patients with the 2 widely used 11C-MET and 18F-FDOPA PET amino acid tracers. Thirty-two 11C-MET and 26 18F-FDOPA PET scans with amino acid PET-negative gliomas were selected in this European multicentric study. Of these gliomas, 16 11C-MET and 10 18F-FDOPA PET scans with photopenic defects were identified, exhibiting lower mean tumor-to-background ratio as compared with isometabolic gliomas (P < 0.001). Gliomas with photopenic defects had no different progression-free survival than isometabolic gliomas in the whole population (P = 0.40), but shorter progression-free survival in the subgroup of World Health Organization grade II IDH-mutant astrocytomas (35 vs 68 months; P = 0.047).
LB  - PUB:(DE-HGF)16
C6  - pmid:32804767
UR  - <Go to ISI:>//WOS:000600422200022
DO  - DOI:10.1097/RLU.0000000000003240
UR  - https://juser.fz-juelich.de/record/890483
ER  -