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@ARTICLE{Zaragori:890483,
      author       = {Zaragori, Timothée and Castello, Angelo and Guedj, Eric
                      and Girard, Antoine and Galldiks, Norbert and Albert,
                      Nathalie L. and Lopci, Egesta and Verger, Antoine},
      title        = {{P}hotopenic {D}efects in {G}liomas {W}ith {A}mino-{A}cid
                      {PET} and {R}elative {P}rognostic {V}alue},
      journal      = {Clinical nuclear medicine},
      volume       = {46},
      number       = {1},
      issn         = {1536-0229},
      address      = {[S.l.]},
      publisher    = {Ovid},
      reportid     = {FZJ-2021-00991},
      pages        = {e36 - e37},
      year         = {2021},
      abstract     = {The aim is to explore the concept of photopenic defects in
                      newly diagnosed glioma patients with the 2 widely used
                      11C-MET and 18F-FDOPA PET amino acid tracers. Thirty-two
                      11C-MET and 26 18F-FDOPA PET scans with amino acid
                      PET-negative gliomas were selected in this European
                      multicentric study. Of these gliomas, 16 11C-MET and 10
                      18F-FDOPA PET scans with photopenic defects were identified,
                      exhibiting lower mean tumor-to-background ratio as compared
                      with isometabolic gliomas (P < 0.001). Gliomas with
                      photopenic defects had no different progression-free
                      survival than isometabolic gliomas in the whole population
                      (P = 0.40), but shorter progression-free survival in the
                      subgroup of World Health Organization grade II IDH-mutant
                      astrocytomas (35 vs 68 months; P = 0.047).},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {525 - Decoding Brain Organization and Dysfunction
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-525},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32804767},
      UT           = {WOS:000600422200022},
      doi          = {10.1097/RLU.0000000000003240},
      url          = {https://juser.fz-juelich.de/record/890483},
}