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100 1 _ |a Zaragori, Timothée
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245 _ _ |a Photopenic Defects in Gliomas With Amino-Acid PET and Relative Prognostic Value
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520 _ _ |a The aim is to explore the concept of photopenic defects in newly diagnosed glioma patients with the 2 widely used 11C-MET and 18F-FDOPA PET amino acid tracers. Thirty-two 11C-MET and 26 18F-FDOPA PET scans with amino acid PET-negative gliomas were selected in this European multicentric study. Of these gliomas, 16 11C-MET and 10 18F-FDOPA PET scans with photopenic defects were identified, exhibiting lower mean tumor-to-background ratio as compared with isometabolic gliomas (P < 0.001). Gliomas with photopenic defects had no different progression-free survival than isometabolic gliomas in the whole population (P = 0.40), but shorter progression-free survival in the subgroup of World Health Organization grade II IDH-mutant astrocytomas (35 vs 68 months; P = 0.047).
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700 1 _ |a Castello, Angelo
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700 1 _ |a Guedj, Eric
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700 1 _ |a Girard, Antoine
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700 1 _ |a Galldiks, Norbert
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700 1 _ |a Albert, Nathalie L.
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700 1 _ |a Lopci, Egesta
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700 1 _ |a Verger, Antoine
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773 _ _ |a 10.1097/RLU.0000000000003240
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856 4 _ |y Published on 2021-01-01. Available in OpenAccess from 2022-01-01.
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