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@ARTICLE{Hilgers:890513,
      author       = {Hilgers, Fabienne and Habash, Samer S. and Loeschcke, Anita
                      and Ackermann, Yannic and Neumann, Stefan and Heck, Achim
                      and Klaus, Oliver and Hage-Hülsmann, Jennifer and Grundler,
                      Florian M. W. and Jaeger, Karl-Erich and Sylvia S. Schleker,
                      A. and Drepper, Thomas},
      title        = {{H}eterologous {P}roduction of β-{C}aryophyllene and
                      {E}valuation of {I}ts {A}ctivity against {P}lant
                      {P}athogenic {F}ungi},
      journal      = {Microorganisms},
      volume       = {9},
      number       = {1},
      issn         = {2076-2607},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {FZJ-2021-01004},
      pages        = {168 -},
      year         = {2021},
      abstract     = {Terpenoids constitute one of the largest and most diverse
                      groups within the class of secondary metabolites, comprising
                      over 80,000 compounds. They not only exhibit important
                      functions in plant physiology but also have commercial
                      potential in the biotechnological, pharmaceutical, and
                      agricultural sectors due to their promising properties,
                      including various bioactivities against pathogens,
                      inflammations, and cancer. In this work, we therefore aimed
                      to implement the plant sesquiterpenoid pathway leading to
                      β-caryophyllene in the heterologous host Rhodobacter
                      capsulatus and achieved a maximum production of 139 ± 31 mg
                      L−1 culture. As this sesquiterpene offers various
                      beneficial anti-phytopathogenic activities, we evaluated the
                      bioactivity of β-caryophyllene and its oxygenated
                      derivative β-caryophyllene oxide against different
                      phytopathogenic fungi. Here, both compounds significantly
                      inhibited the growth of Sclerotinia sclerotiorum and
                      Fusarium oxysporum by up to $40\%,$ while growth of
                      Alternaria brassicicola was only slightly affected, and
                      Phoma lingam and Rhizoctonia solani were unaffected. At the
                      same time, the compounds showed a promising low inhibitory
                      profile for a variety of plant growth-promoting bacteria at
                      suitable compound concentrations. Our observations thus give
                      a first indication that β-caryophyllene and
                      β-caryophyllene oxide are promising natural agents, which
                      might be applicable for the management of certain plant
                      pathogenic fungi in agricultural crop production.},
      cin          = {IMET / IBG-1},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IMET-20090612 / I:(DE-Juel1)IBG-1-20101118},
      pnm          = {217 - Für eine nachhaltige Bio-Ökonomie – von
                      Ressourcen zu Produkten (POF4-217) / 2172 - Utilization of
                      renewable carbon and energy sources and engineering of
                      ecosystem functions (POF4-217)},
      pid          = {G:(DE-HGF)POF4-217 / G:(DE-HGF)POF4-2172},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33466643},
      UT           = {WOS:000610578900001},
      doi          = {10.3390/microorganisms9010168},
      url          = {https://juser.fz-juelich.de/record/890513},
}