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000890547 1001_ $$0P:(DE-Juel1)166110$$aBittner, Nora$$b0$$ufzj
000890547 245__ $$aWhen your brain looks older than expected: combined lifestyle risk and BrainAGE.
000890547 260__ $$aHeidelberg$$bSpringer$$c2021
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000890547 520__ $$aLifestyle may be one source of unexplained variance in the great interindividual variability of the brain in age-related structural differences. While physical and social activity may protect against structural decline, other lifestyle behaviors may be accelerating factors. We examined whether riskier lifestyle correlates with accelerated brain aging using the BrainAGE score in 622 older adults from the 1000BRAINS cohort. Lifestyle was measured using a combined lifestyle risk score, composed of risk (smoking, alcohol intake) and protective variables (social integration and physical activity). We estimated individual BrainAGE from T1-weighted MRI data indicating accelerated brain atrophy by higher values. Then, the effect of combined lifestyle risk and individual lifestyle variables was regressed against BrainAGE. One unit increase in combined lifestyle risk predicted 5.04 months of additional BrainAGE. This prediction was driven by smoking (0.6 additional months of BrainAGE per pack-year) and physical activity (0.55 less months in BrainAGE per metabolic equivalent). Stratification by sex revealed a stronger association between physical activity and BrainAGE in males than females. Overall, our observations may be helpful with regard to lifestyle-related tailored prevention measures that slow changes in brain structure in older adults.
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000890547 650_7 $$2Other$$aLifestyle
000890547 650_7 $$2Other$$aMR-based age estimation
000890547 650_7 $$2Other$$aMR-morphometry
000890547 650_7 $$2Other$$aPhysical activity
000890547 650_7 $$2Other$$aSmoking
000890547 7001_ $$0P:(DE-Juel1)145386$$aJockwitz, Christiane$$b1$$ufzj
000890547 7001_ $$0P:(DE-HGF)0$$aFranke, Katja$$b2
000890547 7001_ $$0P:(DE-HGF)0$$aGaser, Christian$$b3
000890547 7001_ $$0P:(DE-HGF)0$$aMoebus, Susanne$$b4
000890547 7001_ $$0P:(DE-HGF)0$$aBayen, Ute J$$b5
000890547 7001_ $$0P:(DE-Juel1)131631$$aAmunts, Katrin$$b6$$ufzj
000890547 7001_ $$0P:(DE-Juel1)131675$$aCaspers, Svenja$$b7$$eCorresponding author$$ufzj
000890547 773__ $$0PERI:(DE-600)2303775-1$$a10.1007/s00429-020-02184-6$$p621–645$$tBrain structure & function$$v226$$x1863-2661$$y2021
000890547 8564_ $$uhttps://juser.fz-juelich.de/record/890547/files/Bittner2021_Article_WhenYourBrainLooksOlderThanExp.pdf$$yOpenAccess
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