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@ARTICLE{Bittner:890547,
      author       = {Bittner, Nora and Jockwitz, Christiane and Franke, Katja
                      and Gaser, Christian and Moebus, Susanne and Bayen, Ute J
                      and Amunts, Katrin and Caspers, Svenja},
      title        = {{W}hen your brain looks older than expected: combined
                      lifestyle risk and {B}rain{AGE}.},
      journal      = {Brain structure $\&$ function},
      volume       = {226},
      issn         = {1863-2661},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {FZJ-2021-01029},
      pages        = {621–645},
      year         = {2021},
      abstract     = {Lifestyle may be one source of unexplained variance in the
                      great interindividual variability of the brain in
                      age-related structural differences. While physical and
                      social activity may protect against structural decline,
                      other lifestyle behaviors may be accelerating factors. We
                      examined whether riskier lifestyle correlates with
                      accelerated brain aging using the BrainAGE score in 622
                      older adults from the 1000BRAINS cohort. Lifestyle was
                      measured using a combined lifestyle risk score, composed of
                      risk (smoking, alcohol intake) and protective variables
                      (social integration and physical activity). We estimated
                      individual BrainAGE from T1-weighted MRI data indicating
                      accelerated brain atrophy by higher values. Then, the effect
                      of combined lifestyle risk and individual lifestyle
                      variables was regressed against BrainAGE. One unit increase
                      in combined lifestyle risk predicted 5.04 months of
                      additional BrainAGE. This prediction was driven by smoking
                      (0.6 additional months of BrainAGE per pack-year) and
                      physical activity (0.55 less months in BrainAGE per
                      metabolic equivalent). Stratification by sex revealed a
                      stronger association between physical activity and BrainAGE
                      in males than females. Overall, our observations may be
                      helpful with regard to lifestyle-related tailored prevention
                      measures that slow changes in brain structure in older
                      adults.},
      keywords     = {Lifestyle (Other) / MR-based age estimation (Other) /
                      MR-morphometry (Other) / Physical activity (Other) / Smoking
                      (Other)},
      cin          = {INM-1 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406 / $I:(DE-82)080010_20140620$},
      pnm          = {525 - Decoding Brain Organization and Dysfunction
                      (POF4-525) / HBP SGA2 - Human Brain Project Specific Grant
                      Agreement 2 (785907) / HBP SGA3 - Human Brain Project
                      Specific Grant Agreement 3 (945539)},
      pid          = {G:(DE-HGF)POF4-525 / G:(EU-Grant)785907 /
                      G:(EU-Grant)945539},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33423086},
      UT           = {WOS:000606725700001},
      doi          = {10.1007/s00429-020-02184-6},
      url          = {https://juser.fz-juelich.de/record/890547},
}