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@ARTICLE{Schmitt:890554,
      author       = {Schmitt, Laura and Hinxlage, Ilka and Cea, Pablo A. and
                      Gohlke, Holger and Wesselborg, Sebastian},
      title        = {40 {Y}ears of {R}esearch on {P}olybrominated {D}iphenyl
                      {E}thers ({PBDE}s)—{A} {H}istorical {O}verview and
                      {N}ewest {D}ata of a {P}romising {A}nticancer {D}rug},
      journal      = {Molecules},
      volume       = {26},
      number       = {4},
      issn         = {1420-3049},
      address      = {Basel},
      publisher    = {MDPI70206},
      reportid     = {FZJ-2021-01036},
      pages        = {995 -},
      year         = {2021},
      abstract     = {Polybrominated diphenyl ethers (PBDEs) are a group of
                      molecules with an ambiguous background in literature. PBDEs
                      were first isolated from marine sponges of Dysidea species
                      in 1981 and have been under continuous research to the
                      present day. This article summarizes the two research
                      aspects, (i) the marine compound chemistry research dealing
                      with naturally produced PBDEs and (ii) the environmental
                      toxicology research dealing with synthetically-produced
                      brominated flame-retardant PBDEs. The different bioactivity
                      patterns are set in relation to the structural similarities
                      and dissimilarities between both groups. In addition, this
                      article gives a first structure–activity relationship
                      analysis comparing both groups of PBDEs. Moreover, we
                      provide novel data of a promising anticancer therapeutic
                      PBDE (i.e.,
                      4,5,6-tribromo-2-(2′,4′-dibromophenoxy)phenol; termed
                      P01F08). It has been known since 1995 that P01F08 exhibits
                      anticancer activity, but the detailed mechanism remains
                      poorly understood. Only recently, Mayer and colleagues
                      identified a therapeutic window for P01F08, specifically
                      targeting primary malignant cells in a low µM range. To
                      elucidate the mechanistic pathway of cell death induction,
                      we verified and compared its cytotoxicity and apoptosis
                      induction capacity in Ramos and Jurkat lymphoma cells.
                      Moreover, using Jurkat cells overexpressing antiapoptotic
                      Bcl-2, we were able to show that P01F08 induces apoptosis
                      mainly through the intrinsic mitochondrial pathway.},
      cin          = {JSC / NIC / IBI-7},
      ddc          = {540},
      cid          = {I:(DE-Juel1)JSC-20090406 / I:(DE-Juel1)NIC-20090406 /
                      I:(DE-Juel1)IBI-7-20200312},
      pnm          = {5111 - Domain-Specific Simulation $\&$ Data Life Cycle Labs
                      (SDLs) and Research Groups (POF4-511) / Forschergruppe
                      Gohlke $(hkf7_20200501)$},
      pid          = {G:(DE-HGF)POF4-5111 / $G:(DE-Juel1)hkf7_20200501$},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33668501},
      UT           = {WOS:000624166200001},
      doi          = {10.3390/molecules26040995},
      url          = {https://juser.fz-juelich.de/record/890554},
}