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@ARTICLE{Hahn:890579,
      author       = {Hahn, Lisa and Eickhoff, Simon B. and Habel, Ute and
                      Stickeler, Elmar and Schnakenberg, Patricia and Goecke,
                      Tamme W. and Stickel, Susanne and Franz, Matthias and
                      Dukart, Juergen and Chechko, Natalia},
      title        = {{E}arly identification of postpartum depression using
                      demographic, clinical, and digital phenotyping},
      journal      = {Translational Psychiatry},
      volume       = {11},
      number       = {1},
      issn         = {2158-3188},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {FZJ-2021-01045},
      pages        = {121},
      year         = {2021},
      note         = {410314797/Deutsche Forschungsgemeinschaft (German Research
                      Foundation) 410314797/Deutsche Forschungsgemeinschaft
                      (German Research Foundation) 410314797/Deutsche
                      Forschungsgemeinschaft (German Research Foundation)
                      410314797/Deutsche Forschungsgemeinschaft (German Research
                      Foundation) 785907/EC | Horizon 2020 Framework Programme (EU
                      Framework Programme for Research and Innovation H2020) The
                      study was supported by the DFG (Grant number: 410314797). NC
                      wassupported by the Clinical Scientist Program (rotation
                      program) of the medicalfaculty RWTH, Aachen (2015–2017).
                      S.B.E. was supported by the EuropeanUnion’s Horizon 2020
                      Research and Innovation Programme under GrantAgreement No.
                      785907 (HBP SGA2). Open Access funding enabled andorganized
                      by Projekt DEAL.},
      abstract     = {Postpartum depression (PPD) and adjustment disorder (AD)
                      affect up to $25\%$ of women after childbirth. However,
                      there are no accurate screening tools for either disorder to
                      identify at-risk mothers and enable them to benefit from
                      early intervention. Combinations of anamnestic, clinical,
                      and remote assessments were evaluated for an early and
                      accurate identification of PPD and AD. Two cohorts of
                      mothers giving birth were included in the study (N = 308 and
                      N = 193). At baseline, participants underwent a detailed
                      sociodemographic-anamnestic and clinical interview. Remote
                      assessments were collected over 12 weeks comprising mood and
                      stress levels as well as depression and attachment scores.
                      At 12 weeks postpartum, an experienced clinician assigned
                      the participants to three distinct groups: women with PPD,
                      women with AD, and healthy controls (HC). Combinations of
                      these assessments were assessed for an early an accurate
                      detection of PPD and AD in the first cohort and, after
                      pre-registration, validated in a prospective second cohort.
                      Combinations of postnatal depression, attachment (for AD)
                      and mood scores at week 3 achieved balanced accuracies of 93
                      and $79\%$ for differentiation of PPD and AD from HC in the
                      validation cohort and balanced accuracies of 87 and $91\%$
                      in the first cohort. Differentiation between AD and PPD,
                      with a balanced accuracy of $73\%$ was possible at week 6
                      based on mood levels only with a balanced accuracy of $73\%$
                      in the validation cohort and a balanced accuracy of $76\%$
                      in the first cohort. Combinations of in clinic and remote
                      self-assessments allow for early and accurate detection of
                      PPD and AD as early as three weeks postpartum, enabling
                      early intervention to the benefit of both mothers and
                      children.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {525 - Decoding Brain Organization and Dysfunction
                      (POF4-525) / HBP SGA2 - Human Brain Project Specific Grant
                      Agreement 2 (785907)},
      pid          = {G:(DE-HGF)POF4-525 / G:(EU-Grant)785907},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33574229},
      UT           = {WOS:000620084800001},
      doi          = {10.1038/s41398-021-01245-6},
      url          = {https://juser.fz-juelich.de/record/890579},
}